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Platelet Function in Aging

Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular d...

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Detalles Bibliográficos
Autores principales: Le Blanc, Jessica, Lordkipanidzé, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692461/
https://www.ncbi.nlm.nih.gov/pubmed/31448291
http://dx.doi.org/10.3389/fcvm.2019.00109
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author Le Blanc, Jessica
Lordkipanidzé, Marie
author_facet Le Blanc, Jessica
Lordkipanidzé, Marie
author_sort Le Blanc, Jessica
collection PubMed
description Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
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spelling pubmed-66924612019-08-23 Platelet Function in Aging Le Blanc, Jessica Lordkipanidzé, Marie Front Cardiovasc Med Cardiovascular Medicine Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease. Frontiers Media S.A. 2019-08-07 /pmc/articles/PMC6692461/ /pubmed/31448291 http://dx.doi.org/10.3389/fcvm.2019.00109 Text en Copyright © 2019 Le Blanc and Lordkipanidzé. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Le Blanc, Jessica
Lordkipanidzé, Marie
Platelet Function in Aging
title Platelet Function in Aging
title_full Platelet Function in Aging
title_fullStr Platelet Function in Aging
title_full_unstemmed Platelet Function in Aging
title_short Platelet Function in Aging
title_sort platelet function in aging
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692461/
https://www.ncbi.nlm.nih.gov/pubmed/31448291
http://dx.doi.org/10.3389/fcvm.2019.00109
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