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Platelet Function in Aging
Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692461/ https://www.ncbi.nlm.nih.gov/pubmed/31448291 http://dx.doi.org/10.3389/fcvm.2019.00109 |
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author | Le Blanc, Jessica Lordkipanidzé, Marie |
author_facet | Le Blanc, Jessica Lordkipanidzé, Marie |
author_sort | Le Blanc, Jessica |
collection | PubMed |
description | Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease. |
format | Online Article Text |
id | pubmed-6692461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66924612019-08-23 Platelet Function in Aging Le Blanc, Jessica Lordkipanidzé, Marie Front Cardiovasc Med Cardiovascular Medicine Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease. Frontiers Media S.A. 2019-08-07 /pmc/articles/PMC6692461/ /pubmed/31448291 http://dx.doi.org/10.3389/fcvm.2019.00109 Text en Copyright © 2019 Le Blanc and Lordkipanidzé. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Le Blanc, Jessica Lordkipanidzé, Marie Platelet Function in Aging |
title | Platelet Function in Aging |
title_full | Platelet Function in Aging |
title_fullStr | Platelet Function in Aging |
title_full_unstemmed | Platelet Function in Aging |
title_short | Platelet Function in Aging |
title_sort | platelet function in aging |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692461/ https://www.ncbi.nlm.nih.gov/pubmed/31448291 http://dx.doi.org/10.3389/fcvm.2019.00109 |
work_keys_str_mv | AT leblancjessica plateletfunctioninaging AT lordkipanidzemarie plateletfunctioninaging |