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GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In...

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Detalles Bibliográficos
Autores principales: Fan, Chunmei, Tu, Chaofeng, Qi, Peng, Guo, Can, Xiang, Bo, Zhou, Ming, Li, Xiayu, Wu, Xu, Li, Xiaoling, Li, Guiyuan, Xiong, Wei, Zeng, Zhaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692608/
https://www.ncbi.nlm.nih.gov/pubmed/31417636
http://dx.doi.org/10.7150/jca.31345
Descripción
Sumario:Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In our previous study, we conducted whole-genome sequencing to screen for genomic variations that were associated with NPC. Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional experiments, which demonstrated that GPC6 promotes the migration, invasion, and proliferation of NPC cells in vitro. Thus, the present study identified novel biological functions for GPC6 in NPC, and thus, showed that GPC6 may be a promising potential therapeutic target for this disease.