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GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692608/ https://www.ncbi.nlm.nih.gov/pubmed/31417636 http://dx.doi.org/10.7150/jca.31345 |
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author | Fan, Chunmei Tu, Chaofeng Qi, Peng Guo, Can Xiang, Bo Zhou, Ming Li, Xiayu Wu, Xu Li, Xiaoling Li, Guiyuan Xiong, Wei Zeng, Zhaoyang |
author_facet | Fan, Chunmei Tu, Chaofeng Qi, Peng Guo, Can Xiang, Bo Zhou, Ming Li, Xiayu Wu, Xu Li, Xiaoling Li, Guiyuan Xiong, Wei Zeng, Zhaoyang |
author_sort | Fan, Chunmei |
collection | PubMed |
description | Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In our previous study, we conducted whole-genome sequencing to screen for genomic variations that were associated with NPC. Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional experiments, which demonstrated that GPC6 promotes the migration, invasion, and proliferation of NPC cells in vitro. Thus, the present study identified novel biological functions for GPC6 in NPC, and thus, showed that GPC6 may be a promising potential therapeutic target for this disease. |
format | Online Article Text |
id | pubmed-6692608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-66926082019-08-15 GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma Fan, Chunmei Tu, Chaofeng Qi, Peng Guo, Can Xiang, Bo Zhou, Ming Li, Xiayu Wu, Xu Li, Xiaoling Li, Guiyuan Xiong, Wei Zeng, Zhaoyang J Cancer Research Paper Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In our previous study, we conducted whole-genome sequencing to screen for genomic variations that were associated with NPC. Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional experiments, which demonstrated that GPC6 promotes the migration, invasion, and proliferation of NPC cells in vitro. Thus, the present study identified novel biological functions for GPC6 in NPC, and thus, showed that GPC6 may be a promising potential therapeutic target for this disease. Ivyspring International Publisher 2019-06-24 /pmc/articles/PMC6692608/ /pubmed/31417636 http://dx.doi.org/10.7150/jca.31345 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Fan, Chunmei Tu, Chaofeng Qi, Peng Guo, Can Xiang, Bo Zhou, Ming Li, Xiayu Wu, Xu Li, Xiaoling Li, Guiyuan Xiong, Wei Zeng, Zhaoyang GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title | GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title_full | GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title_fullStr | GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title_full_unstemmed | GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title_short | GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma |
title_sort | gpc6 promotes cell proliferation, migration, and invasion in nasopharyngeal carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692608/ https://www.ncbi.nlm.nih.gov/pubmed/31417636 http://dx.doi.org/10.7150/jca.31345 |
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