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Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial

Purpose: To compare the clinicopathologic data and short-term surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer (GC) between the east and west. Methods: Patient demographics, surgical procedures, pathological information, and postoperative recovery were compared among gastric can...

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Autores principales: Lin, Jian-Xian, Lin, Jun-Peng, Desiderio, Jacopo, Xie, Jian-Wei, Gemini, Alessandro, Wang, Jia-bin, Lu, Jun, Chen, Qi-Yue, Cao, Long-long, Lin, Mi, Tu, Ruhong, Zheng, Chao-Hui, Li, Ping, Parisi, Amilcare, Huang, Chang-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692614/
https://www.ncbi.nlm.nih.gov/pubmed/31417655
http://dx.doi.org/10.7150/jca.31192
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author Lin, Jian-Xian
Lin, Jun-Peng
Desiderio, Jacopo
Xie, Jian-Wei
Gemini, Alessandro
Wang, Jia-bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-long
Lin, Mi
Tu, Ruhong
Zheng, Chao-Hui
Li, Ping
Parisi, Amilcare
Huang, Chang-Ming
author_facet Lin, Jian-Xian
Lin, Jun-Peng
Desiderio, Jacopo
Xie, Jian-Wei
Gemini, Alessandro
Wang, Jia-bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-long
Lin, Mi
Tu, Ruhong
Zheng, Chao-Hui
Li, Ping
Parisi, Amilcare
Huang, Chang-Ming
author_sort Lin, Jian-Xian
collection PubMed
description Purpose: To compare the clinicopathologic data and short-term surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer (GC) between the east and west. Methods: Patient demographics, surgical procedures, pathological information, and postoperative recovery were compared among gastric cancer patients who underwent LG in the clinical trial of IMIGASTRIC (NCT02325453) between 2009 and 2016. Results: More younger males, higher BMI, lower ASA score and less neoadjvant chemotherapy were evident in east patient cohort. Eastern patients had a higher proportion of proximal, differentiated and advanced gastric cancers. More total gastrectomies, larger extent of lymph node (LN) dissection, and higher number of retrieved LNs were found in the eastern patients. However, more Roux-en-Y anastomosis procedures during distal gastrectomy and intra-corporeal anastomosis were performed in the western patients. The west patients showed faster postoperative recovery than the eastern patients. The mortality rates of the western patients were comparable to those of the eastern patients. However, fewer III-IV complications were evident in the eastern centers. Multivariate analyses revealed that an elderly age, higher ASA score, and more blood loss were the significant independent risk factors of postoperative complications for eastern patients. However, for the western patients, the independent risk factors were neoadjuvant therapy, more retrieval LNs, and pT3-4 stage. Conclusions: The selections and short-term surgical outcomes of LG for GC were widely different between East and West. To obtain more objective and accurate results, these differences should be considered in future international prospective studies.
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spelling pubmed-66926142019-08-15 Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial Lin, Jian-Xian Lin, Jun-Peng Desiderio, Jacopo Xie, Jian-Wei Gemini, Alessandro Wang, Jia-bin Lu, Jun Chen, Qi-Yue Cao, Long-long Lin, Mi Tu, Ruhong Zheng, Chao-Hui Li, Ping Parisi, Amilcare Huang, Chang-Ming J Cancer Research Paper Purpose: To compare the clinicopathologic data and short-term surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer (GC) between the east and west. Methods: Patient demographics, surgical procedures, pathological information, and postoperative recovery were compared among gastric cancer patients who underwent LG in the clinical trial of IMIGASTRIC (NCT02325453) between 2009 and 2016. Results: More younger males, higher BMI, lower ASA score and less neoadjvant chemotherapy were evident in east patient cohort. Eastern patients had a higher proportion of proximal, differentiated and advanced gastric cancers. More total gastrectomies, larger extent of lymph node (LN) dissection, and higher number of retrieved LNs were found in the eastern patients. However, more Roux-en-Y anastomosis procedures during distal gastrectomy and intra-corporeal anastomosis were performed in the western patients. The west patients showed faster postoperative recovery than the eastern patients. The mortality rates of the western patients were comparable to those of the eastern patients. However, fewer III-IV complications were evident in the eastern centers. Multivariate analyses revealed that an elderly age, higher ASA score, and more blood loss were the significant independent risk factors of postoperative complications for eastern patients. However, for the western patients, the independent risk factors were neoadjuvant therapy, more retrieval LNs, and pT3-4 stage. Conclusions: The selections and short-term surgical outcomes of LG for GC were widely different between East and West. To obtain more objective and accurate results, these differences should be considered in future international prospective studies. Ivyspring International Publisher 2019-07-10 /pmc/articles/PMC6692614/ /pubmed/31417655 http://dx.doi.org/10.7150/jca.31192 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lin, Jian-Xian
Lin, Jun-Peng
Desiderio, Jacopo
Xie, Jian-Wei
Gemini, Alessandro
Wang, Jia-bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-long
Lin, Mi
Tu, Ruhong
Zheng, Chao-Hui
Li, Ping
Parisi, Amilcare
Huang, Chang-Ming
Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title_full Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title_fullStr Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title_full_unstemmed Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title_short Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
title_sort difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the imigastric trial
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692614/
https://www.ncbi.nlm.nih.gov/pubmed/31417655
http://dx.doi.org/10.7150/jca.31192
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