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Novel preoperative nutritional assessment tool and prognostic model for ESCC patients

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumor types worldwide, and malnutrition prevails in these patients. However, there is no preoperative nutritional assessment tool specifically designed for patients with ESCC. Methods: Patients who received esophagec...

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Autores principales: Xu, Jinming, Cao, Jinlin, Wang, Ying, Yao, Xin, Wang, Yiqing, He, Zhehao, Lv, Wang, Hu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692628/
https://www.ncbi.nlm.nih.gov/pubmed/31417631
http://dx.doi.org/10.7150/jca.31286
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author Xu, Jinming
Cao, Jinlin
Wang, Ying
Yao, Xin
Wang, Yiqing
He, Zhehao
Lv, Wang
Hu, Jian
author_facet Xu, Jinming
Cao, Jinlin
Wang, Ying
Yao, Xin
Wang, Yiqing
He, Zhehao
Lv, Wang
Hu, Jian
author_sort Xu, Jinming
collection PubMed
description Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumor types worldwide, and malnutrition prevails in these patients. However, there is no preoperative nutritional assessment tool specifically designed for patients with ESCC. Methods: Patients who received esophagectomy from 2004 to 2016 were consecutively included. The preoperative nutritional risk factors for ESCC were screened by univariate and multivariate Cox regression analysis to construct a new nutritional scoring tool. A prognostic model of ESCC based on the new scoring tool was further proposed. Results: A total of 510 ESCC patients were enrolled. A novel BLUT (BMI-lymphocyte-uric acid-triglyceride) scoring tool based on BMI, lymphocyte count, uric acid level, and triglyceride level was proposed, which could effectively predict the prognosis of ESCC patients (log rank P<0.001), and it was better than the traditional nutritional assessment tools. The C-index and 95% confidence interval (CI) of the nomogram based on the BLUT scoring tool was 0.735(0.698-0.772). It had good prognostic efficacy and was significantly better than the model based on T stage and N stage (P=0.038). The calibration curve of internal and external validation suggested a good fitting effect with the real situation in judging the 1-year, 3-year, and 5-year survival status. Conclusions: The BULT scoring tool could distinguish the heterogeneity of preoperative nutritional status and the BLUT-based nomogram had good prognostic performance for ESCC patients.
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spelling pubmed-66926282019-08-15 Novel preoperative nutritional assessment tool and prognostic model for ESCC patients Xu, Jinming Cao, Jinlin Wang, Ying Yao, Xin Wang, Yiqing He, Zhehao Lv, Wang Hu, Jian J Cancer Research Paper Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumor types worldwide, and malnutrition prevails in these patients. However, there is no preoperative nutritional assessment tool specifically designed for patients with ESCC. Methods: Patients who received esophagectomy from 2004 to 2016 were consecutively included. The preoperative nutritional risk factors for ESCC were screened by univariate and multivariate Cox regression analysis to construct a new nutritional scoring tool. A prognostic model of ESCC based on the new scoring tool was further proposed. Results: A total of 510 ESCC patients were enrolled. A novel BLUT (BMI-lymphocyte-uric acid-triglyceride) scoring tool based on BMI, lymphocyte count, uric acid level, and triglyceride level was proposed, which could effectively predict the prognosis of ESCC patients (log rank P<0.001), and it was better than the traditional nutritional assessment tools. The C-index and 95% confidence interval (CI) of the nomogram based on the BLUT scoring tool was 0.735(0.698-0.772). It had good prognostic efficacy and was significantly better than the model based on T stage and N stage (P=0.038). The calibration curve of internal and external validation suggested a good fitting effect with the real situation in judging the 1-year, 3-year, and 5-year survival status. Conclusions: The BULT scoring tool could distinguish the heterogeneity of preoperative nutritional status and the BLUT-based nomogram had good prognostic performance for ESCC patients. Ivyspring International Publisher 2019-06-10 /pmc/articles/PMC6692628/ /pubmed/31417631 http://dx.doi.org/10.7150/jca.31286 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Xu, Jinming
Cao, Jinlin
Wang, Ying
Yao, Xin
Wang, Yiqing
He, Zhehao
Lv, Wang
Hu, Jian
Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title_full Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title_fullStr Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title_full_unstemmed Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title_short Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
title_sort novel preoperative nutritional assessment tool and prognostic model for escc patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692628/
https://www.ncbi.nlm.nih.gov/pubmed/31417631
http://dx.doi.org/10.7150/jca.31286
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