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Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations

[Image: see text] A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for ca...

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Autores principales: Sánchez-Fernández, María J., Immers, Mikey R., Félix Lanao, Rosa P., Yang, Fang, Bender, Johan C. M. E., Mecinović, Jasmin, Leeuwenburgh, Sander C. G., van Hest, Jan C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692821/
https://www.ncbi.nlm.nih.gov/pubmed/31365234
http://dx.doi.org/10.1021/acs.biomac.9b00104
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author Sánchez-Fernández, María J.
Immers, Mikey R.
Félix Lanao, Rosa P.
Yang, Fang
Bender, Johan C. M. E.
Mecinović, Jasmin
Leeuwenburgh, Sander C. G.
van Hest, Jan C. M.
author_facet Sánchez-Fernández, María J.
Immers, Mikey R.
Félix Lanao, Rosa P.
Yang, Fang
Bender, Johan C. M. E.
Mecinović, Jasmin
Leeuwenburgh, Sander C. G.
van Hest, Jan C. M.
author_sort Sánchez-Fernández, María J.
collection PubMed
description [Image: see text] A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca(2+)-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (K(Ca)(2+) = 2.4 × 10(5) M(–1)) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.
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spelling pubmed-66928212019-08-15 Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations Sánchez-Fernández, María J. Immers, Mikey R. Félix Lanao, Rosa P. Yang, Fang Bender, Johan C. M. E. Mecinović, Jasmin Leeuwenburgh, Sander C. G. van Hest, Jan C. M. Biomacromolecules [Image: see text] A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca(2+)-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (K(Ca)(2+) = 2.4 × 10(5) M(–1)) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications. American Chemical Society 2019-07-31 2019-08-12 /pmc/articles/PMC6692821/ /pubmed/31365234 http://dx.doi.org/10.1021/acs.biomac.9b00104 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Sánchez-Fernández, María J.
Immers, Mikey R.
Félix Lanao, Rosa P.
Yang, Fang
Bender, Johan C. M. E.
Mecinović, Jasmin
Leeuwenburgh, Sander C. G.
van Hest, Jan C. M.
Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title_full Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title_fullStr Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title_full_unstemmed Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title_short Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
title_sort alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692821/
https://www.ncbi.nlm.nih.gov/pubmed/31365234
http://dx.doi.org/10.1021/acs.biomac.9b00104
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