Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

BACKGROUND: Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function remains unclear. METHODS: We evaluated mitochondrial function [i.e. oxygen consump...

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Detalles Bibliográficos
Autores principales: Hendriks, Koen D. W., Brüggenwirth, Isabel M. A., Maassen, Hanno, Gerding, Albert, Bakker, Barbara, Porte, Robert J., Henning, Robert H., Leuvenink, Henri G. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693148/
https://www.ncbi.nlm.nih.gov/pubmed/31409351
http://dx.doi.org/10.1186/s12967-019-2013-1

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