DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation

BACKGROUND: Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis, transfor...

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Detalles Bibliográficos
Autores principales: Cui, Haoran, Wang, Qin, Lei, Zhenchuan, Feng, Maoxiao, Zhao, Zhongxi, Wang, Yunshan, Wei, Guangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693180/
https://www.ncbi.nlm.nih.gov/pubmed/31409387
http://dx.doi.org/10.1186/s13046-019-1358-x

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