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The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function

Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, which requires efficient extravasation, activation,...

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Detalles Bibliográficos
Autores principales: Robinson, Brian S., Arthur, Connie M., Evavold, Birk, Roback, Ethan, Kamili, Nourine A., Stowell, Caleb S., Vallecillo-Zúniga, Mary L., Van Ry, Pam M., Dias-Baruffi, Marcelo, Cummings, Richard D., Stowell, Sean R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693361/
https://www.ncbi.nlm.nih.gov/pubmed/31440233
http://dx.doi.org/10.3389/fimmu.2019.01762
Descripción
Sumario:Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, which requires efficient extravasation, activation, chemotaxis, phagocytosis, and eventual killing of potential microbial pathogens. Following pathogen elimination, neutrophils must be eliminated to prevent additional host injury and subsequent exacerbation of the inflammatory response. Galectins, expressed in nearly every tissue and regulated by unique sensitivity to oxidative and proteolytic inactivation, appear to influence nearly every aspect of neutrophil function. In this review, we will examine the impact of galectins on neutrophils, with a particular focus on the unique biochemical traits that allow galectin family members to spatially and temporally regulate neutrophil function.