A Pilot Study of Vinorelbine Safety and Pharmacokinetics in Patients with Varying Degrees of Liver Dysfunction

BACKGROUND. Vinorelbine has demonstrated anticancer activity and is primarily metabolized in the liver. This single‐institution, phase I pilot study describes the safety and pharmacokinetics of vinorelbine in patients with varying degrees of hepatic impairment. MATERIALS AND METHODS. Patients with t...

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Detalles Bibliográficos
Autores principales: Gong, Jun, Cho, May, Gupta, Rohan, Synold, Timothy W., Frankel, Paul, Ruel, Christopher, Fakih, Marwan, Chung, Vincent, Lim, Dean, Chao, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
New Drug Development and Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693729/
https://www.ncbi.nlm.nih.gov/pubmed/30710067
http://dx.doi.org/10.1634/theoncologist.2018-0336

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