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Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts

Murine studies have linked TGF-β signaling to emphysema, and human genome-wide association studies (GWAS) studies of lung function and COPD have identified associated regions near genes in the TGF-β superfamily. However, the functional regulatory mechanisms at these loci have not been identified. We...

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Detalles Bibliográficos
Autores principales:	Parker, Margaret M, Hao, Yuan, Guo, Feng, Pham, Betty, Chase, Robert, Platig, John, Cho, Michael H, Hersh, Craig P, Thannickal, Victor J, Crapo, James, Washko, George, Randell, Scott H, Silverman, Edwin K, San José Estépar, Raúl, Zhou, Xiaobo, Castaldi, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693893/ https://www.ncbi.nlm.nih.gov/pubmed/31343404 http://dx.doi.org/10.7554/eLife.42720

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