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Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alte...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693904/ https://www.ncbi.nlm.nih.gov/pubmed/31453331 http://dx.doi.org/10.1126/sciadv.aaw8357 |
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author | Pavuluri, KowsalyaDevi Manoli, Irini Pass, Alexandra Li, Yuguo Vernon, Hilary J. Venditti, Charles P. McMahon, Michael T. |
author_facet | Pavuluri, KowsalyaDevi Manoli, Irini Pass, Alexandra Li, Yuguo Vernon, Hilary J. Venditti, Charles P. McMahon, Michael T. |
author_sort | Pavuluri, KowsalyaDevi |
collection | PubMed |
description | Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alternative strategy for monitoring renal function based on administration of a pH sensitive MRI agent and assessed this in a mouse model. This protocol produced three metrics: kidney contrast, ~4% for severe renal disease mice compared to ~13% and ~25% for moderate renal disease and healthy controls, filtration fraction (FF), ~15% for severe renal disease mice compared to ~79% and 100% for moderate renal disease and healthy controls, and variation in pH, ~0.45 units for severe disease mice compared to 0.06 and 0.01 for moderate disease and healthy controls. Our results demonstrate that MRI can be used for early detection and monitoring of CKD. |
format | Online Article Text |
id | pubmed-6693904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66939042019-08-26 Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging Pavuluri, KowsalyaDevi Manoli, Irini Pass, Alexandra Li, Yuguo Vernon, Hilary J. Venditti, Charles P. McMahon, Michael T. Sci Adv Research Articles Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alternative strategy for monitoring renal function based on administration of a pH sensitive MRI agent and assessed this in a mouse model. This protocol produced three metrics: kidney contrast, ~4% for severe renal disease mice compared to ~13% and ~25% for moderate renal disease and healthy controls, filtration fraction (FF), ~15% for severe renal disease mice compared to ~79% and 100% for moderate renal disease and healthy controls, and variation in pH, ~0.45 units for severe disease mice compared to 0.06 and 0.01 for moderate disease and healthy controls. Our results demonstrate that MRI can be used for early detection and monitoring of CKD. American Association for the Advancement of Science 2019-08-14 /pmc/articles/PMC6693904/ /pubmed/31453331 http://dx.doi.org/10.1126/sciadv.aaw8357 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Pavuluri, KowsalyaDevi Manoli, Irini Pass, Alexandra Li, Yuguo Vernon, Hilary J. Venditti, Charles P. McMahon, Michael T. Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title | Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title_full | Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title_fullStr | Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title_full_unstemmed | Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title_short | Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging |
title_sort | noninvasive monitoring of chronic kidney disease using ph and perfusion imaging |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693904/ https://www.ncbi.nlm.nih.gov/pubmed/31453331 http://dx.doi.org/10.1126/sciadv.aaw8357 |
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