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Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging

Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alte...

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Autores principales: Pavuluri, KowsalyaDevi, Manoli, Irini, Pass, Alexandra, Li, Yuguo, Vernon, Hilary J., Venditti, Charles P., McMahon, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693904/
https://www.ncbi.nlm.nih.gov/pubmed/31453331
http://dx.doi.org/10.1126/sciadv.aaw8357
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author Pavuluri, KowsalyaDevi
Manoli, Irini
Pass, Alexandra
Li, Yuguo
Vernon, Hilary J.
Venditti, Charles P.
McMahon, Michael T.
author_facet Pavuluri, KowsalyaDevi
Manoli, Irini
Pass, Alexandra
Li, Yuguo
Vernon, Hilary J.
Venditti, Charles P.
McMahon, Michael T.
author_sort Pavuluri, KowsalyaDevi
collection PubMed
description Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alternative strategy for monitoring renal function based on administration of a pH sensitive MRI agent and assessed this in a mouse model. This protocol produced three metrics: kidney contrast, ~4% for severe renal disease mice compared to ~13% and ~25% for moderate renal disease and healthy controls, filtration fraction (FF), ~15% for severe renal disease mice compared to ~79% and 100% for moderate renal disease and healthy controls, and variation in pH, ~0.45 units for severe disease mice compared to 0.06 and 0.01 for moderate disease and healthy controls. Our results demonstrate that MRI can be used for early detection and monitoring of CKD.
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spelling pubmed-66939042019-08-26 Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging Pavuluri, KowsalyaDevi Manoli, Irini Pass, Alexandra Li, Yuguo Vernon, Hilary J. Venditti, Charles P. McMahon, Michael T. Sci Adv Research Articles Chronic Kidney Disease (CKD) is a cardinal feature of methylmalonic acidemia (MMA), a prototypic organic acidemia. Impaired growth, low activity, and protein restriction affect muscle mass and lower serum creatinine, which can delay diagnosis and management of renal disease. We have designed an alternative strategy for monitoring renal function based on administration of a pH sensitive MRI agent and assessed this in a mouse model. This protocol produced three metrics: kidney contrast, ~4% for severe renal disease mice compared to ~13% and ~25% for moderate renal disease and healthy controls, filtration fraction (FF), ~15% for severe renal disease mice compared to ~79% and 100% for moderate renal disease and healthy controls, and variation in pH, ~0.45 units for severe disease mice compared to 0.06 and 0.01 for moderate disease and healthy controls. Our results demonstrate that MRI can be used for early detection and monitoring of CKD. American Association for the Advancement of Science 2019-08-14 /pmc/articles/PMC6693904/ /pubmed/31453331 http://dx.doi.org/10.1126/sciadv.aaw8357 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Pavuluri, KowsalyaDevi
Manoli, Irini
Pass, Alexandra
Li, Yuguo
Vernon, Hilary J.
Venditti, Charles P.
McMahon, Michael T.
Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title_full Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title_fullStr Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title_full_unstemmed Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title_short Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging
title_sort noninvasive monitoring of chronic kidney disease using ph and perfusion imaging
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693904/
https://www.ncbi.nlm.nih.gov/pubmed/31453331
http://dx.doi.org/10.1126/sciadv.aaw8357
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