Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

Atxn7, a subunit of SAGA chromatin remodeling complex, is subject to polyglutamine expansion at the amino terminus, causing spinocerebellar ataxia type 7 (SCA7), a progressive retinal and neurodegenerative disease. Within SAGA, the Atxn7 amino terminus anchors Non-stop, a deubiquitinase, to the comp...

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Detalles Bibliográficos
Autores principales: Cloud, Veronica, Thapa, Ada, Morales-Sosa, Pedro, Miller, Tayla M, Miller, Sara A, Holsapple, Daniel, Gerhart, Paige M, Momtahan, Elaheh, Jack, Jarrid L, Leiva, Edgardo, Rapp, Sarah R, Shelton, Lauren G, Pierce, Richard A, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P, Mohan, Ryan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693919/
https://www.ncbi.nlm.nih.gov/pubmed/31348003
http://dx.doi.org/10.7554/eLife.49677

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