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Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood

Psychosocial and functional outcomes after intestinal resection in pediatric Crohn’s disease (CD) are lacking. Therefore, we (I) assessed health-related quality of life (HRQOL), colorectal function, and satisfaction with surgery and (II) investigated their relationship with surgical outcomes, after...

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Autores principales: Diederen, Kay, de Ridder, Lissy, van Rheenen, Patrick, Wolters, Victorien M., Mearin, Maria L., de Meij, Tim G., van Wering, Herbert, Oomen, Matthijs W., de Jong, Justin R., Sloots, Cornelius E., Benninga, Marc A., Kindermann, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694081/
https://www.ncbi.nlm.nih.gov/pubmed/31327075
http://dx.doi.org/10.1007/s00431-019-03427-3
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author Diederen, Kay
de Ridder, Lissy
van Rheenen, Patrick
Wolters, Victorien M.
Mearin, Maria L.
de Meij, Tim G.
van Wering, Herbert
Oomen, Matthijs W.
de Jong, Justin R.
Sloots, Cornelius E.
Benninga, Marc A.
Kindermann, Angelika
author_facet Diederen, Kay
de Ridder, Lissy
van Rheenen, Patrick
Wolters, Victorien M.
Mearin, Maria L.
de Meij, Tim G.
van Wering, Herbert
Oomen, Matthijs W.
de Jong, Justin R.
Sloots, Cornelius E.
Benninga, Marc A.
Kindermann, Angelika
author_sort Diederen, Kay
collection PubMed
description Psychosocial and functional outcomes after intestinal resection in pediatric Crohn’s disease (CD) are lacking. Therefore, we (I) assessed health-related quality of life (HRQOL), colorectal function, and satisfaction with surgery and (II) investigated their relationship with surgical outcomes, after ileocecal resection for CD. Crohn’s patients that underwent ileocecal resection during childhood were included. HRQOL and colorectal function were assessed using SF-36 and COREFO, respectively, and compared with reference values. Satisfaction was scored on a 5-point Likert scale. In total, 80 patients (50% male, median age 23.0 years) were included. Physical HRQOL was impaired (SF-36 [mean]: CD, 47 vs. general, 54; p < 0.001), while mental HRQOL was similar to that in the general population. Overall colorectal function was impaired (COREFO [mean]: CD, 12.6 vs. normal, 7.2; p < 0.001). Worse colorectal function was associated with increasing clinical disease activity and longer interval since resection. Majority of patients was satisfied with surgery (81% satisfied/very satisfied, 11% neither satisfied nor dissatisfied, 8% dissatisfied/very dissatisfied). Decreased satisfaction with surgery was associated with increased clinical disease activity but not related to colorectal function. Conclusions: Physical HRQOL and colorectal function in CD patients who underwent ileocecal resection during childhood seem impaired and related to adverse surgical outcomes. This emphasizes the need for post-operative monitoring and prophylactic therapies.
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spelling pubmed-66940812019-08-28 Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood Diederen, Kay de Ridder, Lissy van Rheenen, Patrick Wolters, Victorien M. Mearin, Maria L. de Meij, Tim G. van Wering, Herbert Oomen, Matthijs W. de Jong, Justin R. Sloots, Cornelius E. Benninga, Marc A. Kindermann, Angelika Eur J Pediatr Original Article Psychosocial and functional outcomes after intestinal resection in pediatric Crohn’s disease (CD) are lacking. Therefore, we (I) assessed health-related quality of life (HRQOL), colorectal function, and satisfaction with surgery and (II) investigated their relationship with surgical outcomes, after ileocecal resection for CD. Crohn’s patients that underwent ileocecal resection during childhood were included. HRQOL and colorectal function were assessed using SF-36 and COREFO, respectively, and compared with reference values. Satisfaction was scored on a 5-point Likert scale. In total, 80 patients (50% male, median age 23.0 years) were included. Physical HRQOL was impaired (SF-36 [mean]: CD, 47 vs. general, 54; p < 0.001), while mental HRQOL was similar to that in the general population. Overall colorectal function was impaired (COREFO [mean]: CD, 12.6 vs. normal, 7.2; p < 0.001). Worse colorectal function was associated with increasing clinical disease activity and longer interval since resection. Majority of patients was satisfied with surgery (81% satisfied/very satisfied, 11% neither satisfied nor dissatisfied, 8% dissatisfied/very dissatisfied). Decreased satisfaction with surgery was associated with increased clinical disease activity but not related to colorectal function. Conclusions: Physical HRQOL and colorectal function in CD patients who underwent ileocecal resection during childhood seem impaired and related to adverse surgical outcomes. This emphasizes the need for post-operative monitoring and prophylactic therapies. Springer Berlin Heidelberg 2019-07-20 2019 /pmc/articles/PMC6694081/ /pubmed/31327075 http://dx.doi.org/10.1007/s00431-019-03427-3 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Diederen, Kay
de Ridder, Lissy
van Rheenen, Patrick
Wolters, Victorien M.
Mearin, Maria L.
de Meij, Tim G.
van Wering, Herbert
Oomen, Matthijs W.
de Jong, Justin R.
Sloots, Cornelius E.
Benninga, Marc A.
Kindermann, Angelika
Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title_full Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title_fullStr Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title_full_unstemmed Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title_short Quality of life and colorectal function in Crohn’s disease patients that underwent ileocecal resection during childhood
title_sort quality of life and colorectal function in crohn’s disease patients that underwent ileocecal resection during childhood
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694081/
https://www.ncbi.nlm.nih.gov/pubmed/31327075
http://dx.doi.org/10.1007/s00431-019-03427-3
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