A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Besides genome editing, CRISPR-Cas12a has recently been used for DNA detection applications with attomolar sensitivity but, to our knowledge, it has not been used for the detection of small molecules. Bacterial allosteric transcription factors (aTFs) have evolved to sense and respond sensitively to...

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Detalles Bibliográficos
Autores principales: Liang, Mindong, Li, Zilong, Wang, Weishan, Liu, Jiakun, Liu, Leshi, Zhu, Guoliang, Karthik, Loganathan, Wang, Man, Wang, Ke-Feng, Wang, Zhong, Yu, Jing, Shuai, Yuting, Yu, Jiaming, Zhang, Lu, Yang, Zhiheng, Li, Chuan, Zhang, Qian, Shi, Tong, Zhou, Liming, Xie, Feng, Dai, Huanqin, Liu, Xueting, Zhang, Jingyu, Liu, Guang, Zhuo, Ying, Zhang, Buchang, Liu, Chenli, Li, Shanshan, Xia, Xuekui, Tong, Yaojun, Liu, Yanwen, Alterovitz, Gil, Tan, Gao-Yi, Zhang, Li-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694116/
https://www.ncbi.nlm.nih.gov/pubmed/31413315
http://dx.doi.org/10.1038/s41467-019-11648-1

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