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Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mut...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694120/ https://www.ncbi.nlm.nih.gov/pubmed/31413260 http://dx.doi.org/10.1038/s41467-019-11523-z |