Recent advances in understanding the mechanisms determining longevity

The field of aging research has progressed significantly over the past decades. Exogenously and endogenously inflicted molecular damage ranging from genotoxic to organellar damage drives the aging process. Repair mechanisms and compensatory responses counteract the detrimental consequences of the va...

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Detalles Bibliográficos
Autores principales: Bayersdorf, Robert, Schumacher, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694448/
https://www.ncbi.nlm.nih.gov/pubmed/31448092
http://dx.doi.org/10.12688/f1000research.19610.1
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author Bayersdorf, Robert
Schumacher, Björn
author_facet Bayersdorf, Robert
Schumacher, Björn
author_sort Bayersdorf, Robert
collection PubMed
description The field of aging research has progressed significantly over the past decades. Exogenously and endogenously inflicted molecular damage ranging from genotoxic to organellar damage drives the aging process. Repair mechanisms and compensatory responses counteract the detrimental consequences of the various damage types. Here, we discuss recent progress in understanding cellular mechanisms and interconnections between signaling pathways that control longevity. We summarize cell-autonomous and non-cell-autonomous mechanisms that impact the cellular and organismal aging process
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spelling pubmed-66944482019-08-22 Recent advances in understanding the mechanisms determining longevity Bayersdorf, Robert Schumacher, Björn F1000Res Review The field of aging research has progressed significantly over the past decades. Exogenously and endogenously inflicted molecular damage ranging from genotoxic to organellar damage drives the aging process. Repair mechanisms and compensatory responses counteract the detrimental consequences of the various damage types. Here, we discuss recent progress in understanding cellular mechanisms and interconnections between signaling pathways that control longevity. We summarize cell-autonomous and non-cell-autonomous mechanisms that impact the cellular and organismal aging process F1000 Research Limited 2019-08-09 /pmc/articles/PMC6694448/ /pubmed/31448092 http://dx.doi.org/10.12688/f1000research.19610.1 Text en Copyright: © 2019 Bayersdorf R and Schumacher B http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Bayersdorf, Robert
Schumacher, Björn
Recent advances in understanding the mechanisms determining longevity
title Recent advances in understanding the mechanisms determining longevity
title_full Recent advances in understanding the mechanisms determining longevity
title_fullStr Recent advances in understanding the mechanisms determining longevity
title_full_unstemmed Recent advances in understanding the mechanisms determining longevity
title_short Recent advances in understanding the mechanisms determining longevity
title_sort recent advances in understanding the mechanisms determining longevity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694448/
https://www.ncbi.nlm.nih.gov/pubmed/31448092
http://dx.doi.org/10.12688/f1000research.19610.1
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