Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4(+) T cells via miR-302d/MBD2 in systemic lupus erythematosus

BACKGROUND: Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE) patients and associates with the disease activity. In this study, we want to further investigate the mechanism of HERV-E clone 4–1 mRNA upregulation an...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Zhao, Chaoshuai, Zhang, Chengzhong, Mei, Xingyu, Song, Jun, Sun, Yue, Wu, Zhouwei, Shi, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694475/
https://www.ncbi.nlm.nih.gov/pubmed/31412880
http://dx.doi.org/10.1186/s12964-019-0416-5

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