Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2

BACKGROUND: Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis. Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel therapeutic option for liver fibrosis. This study investigated the effects of costunolide, a natural product demonstrate...

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Detalles Bibliográficos
Autores principales: Ban, Dujing, Hua, Shangbo, Zhang, Wen, Shen, Chao, Miao, Xuehua, Liu, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694499/
https://www.ncbi.nlm.nih.gov/pubmed/31428167
http://dx.doi.org/10.1186/s11658-019-0179-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694499/
https://www.ncbi.nlm.nih.gov/pubmed/31428167
http://dx.doi.org/10.1186/s11658-019-0179-4

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