Cargando…
Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2
BACKGROUND: Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis. Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel therapeutic option for liver fibrosis. This study investigated the effects of costunolide, a natural product demonstrate...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694499/ https://www.ncbi.nlm.nih.gov/pubmed/31428167 http://dx.doi.org/10.1186/s11658-019-0179-4 |