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Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case
BACKGROUND: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694504/ https://www.ncbi.nlm.nih.gov/pubmed/31416455 http://dx.doi.org/10.1186/s12903-019-0875-5 |
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author | Setti, Giacomo Martella, Eugenia Mancini, Cristina Vescovi, Paolo Magnoni, Cristina Bellini, Pierantonio Giovannacci, Ilaria Meleti, Marco |
author_facet | Setti, Giacomo Martella, Eugenia Mancini, Cristina Vescovi, Paolo Magnoni, Cristina Bellini, Pierantonio Giovannacci, Ilaria Meleti, Marco |
author_sort | Setti, Giacomo |
collection | PubMed |
description | BACKGROUND: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer. CASE PRESENTATION: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. A clonal T-cell proliferation and CD30 negative immunohistochemical (IHC) profile could be documented. DISCUSSION AND CONCLUSION: In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patient did not report signs of recurrence after a 3-year follow-up period. |
format | Online Article Text |
id | pubmed-6694504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66945042019-08-19 Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case Setti, Giacomo Martella, Eugenia Mancini, Cristina Vescovi, Paolo Magnoni, Cristina Bellini, Pierantonio Giovannacci, Ilaria Meleti, Marco BMC Oral Health Case Report BACKGROUND: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer. CASE PRESENTATION: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. A clonal T-cell proliferation and CD30 negative immunohistochemical (IHC) profile could be documented. DISCUSSION AND CONCLUSION: In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patient did not report signs of recurrence after a 3-year follow-up period. BioMed Central 2019-08-15 /pmc/articles/PMC6694504/ /pubmed/31416455 http://dx.doi.org/10.1186/s12903-019-0875-5 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Setti, Giacomo Martella, Eugenia Mancini, Cristina Vescovi, Paolo Magnoni, Cristina Bellini, Pierantonio Giovannacci, Ilaria Meleti, Marco Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title | Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title_full | Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title_fullStr | Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title_full_unstemmed | Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title_short | Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case |
title_sort | self-healing cd30- t-clonal proliferation of the tongue: report of an extremely rare case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694504/ https://www.ncbi.nlm.nih.gov/pubmed/31416455 http://dx.doi.org/10.1186/s12903-019-0875-5 |
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