An enhanced genetic model of colorectal cancer progression history

BACKGROUND: The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomic alterations, such as genomic rearrangements, are still u...

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Detalles Bibliográficos
Autores principales: Yang, Lixing, Wang, Su, Lee, Jake June-Koo, Lee, Semin, Lee, Eunjung, Shinbrot, Eve, Wheeler, David A., Kucherlapati, Raju, Park, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694562/
https://www.ncbi.nlm.nih.gov/pubmed/31416464
http://dx.doi.org/10.1186/s13059-019-1782-4

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