Cargando…

Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors – implications from studies in KGN

BACKGROUND: Granulosa cell tumors (GCTs) are derived from proliferating granulosa cells of the ovarian follicle. They are known for their late recurrence and most patients with an aggressive form die from their disease. There are no treatment options for this slowly proliferating tumor besides surge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bagnjuk, Konstantin, Kast, Verena Jasmin, Tiefenbacher, Astrid, Kaseder, Melanie, Yanase, Toshihiko, Burges, Alexander, Kunz, Lars, Mayr, Doris, Mayerhofer, Artur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694575/ https://www.ncbi.nlm.nih.gov/pubmed/31412918 http://dx.doi.org/10.1186/s13048-019-0549-6

Ejemplares similares

A Role for H(2)O(2) and TRPM2 in the Induction of Cell Death: Studies in KGN Cells
por: Hack, Carsten Theo, et al.
Publicado: (2019)

Human Luteinized Granulosa Cells—A Cellular Model for the Human Corpus Luteum
por: Bagnjuk, Konstantin, et al.
Publicado: (2019)

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors
por: Schmid, Nina, et al.
Publicado: (2021)

Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN)
por: Asma, Arjoune, et al.
Publicado: (2022)

The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells
por: Buck, Theresa, et al.
Publicado: (2019)

The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors
por: Arjoune, Asma, et al.
Publicado: (2022)

RIPK1 and RIPK3 are positive prognosticators for cervical cancer patients and C2 ceramide can inhibit tumor cell proliferation in vitro
por: Vogelsang, Tilman L. R., et al.
Publicado: (2023)

Dopamine receptor repertoire of human granulosa cells
por: Rey-Ares, Veronica, et al.
Publicado: (2007)

Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro
por: Crosley, Powel, et al.
Publicado: (2021)

Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary
por: Traut, Matthias H, et al.
Publicado: (2009)

RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line
por: Chen, Huachen, et al.
Publicado: (2019)

Effects of omega-3 polyunsaturated fatty acids on cellular development in human ovarian granulosa tumor cells (KGN)
por: Yao, Yilin, et al.
Publicado: (2022)

Excessive levels of diverse phytoestrogens can modulate steroidogenesis and cell migration of KGN human granulosa-derived tumor cells
por: Solak, Kamila A., et al.
Publicado: (2014)

Acetylcholine and necroptosis are players in follicular development in primates
por: Du, Yongrui, et al.
Publicado: (2018)

Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2
por: Eubler, Katja, et al.
Publicado: (2018)

The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors
por: Heublein, Sabine, et al.
Publicado: (2014)

FSH regulates acetycholine production by ovarian granulosa cells
por: Mayerhofer, Artur, et al.
Publicado: (2006)

Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin
por: Tremblay, Patricia G., et al.
Publicado: (2021)

microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor
por: Wu, Yi-xuan, et al.
Publicado: (2021)

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5
por: MacDonald, Julie A., et al.
Publicado: (2018)

Necroptosis in primate luteolysis: a role for ceramide
por: Bagnjuk, Konstantin, et al.
Publicado: (2019)

MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN
por: He, Tingting, et al.
Publicado: (2019)

L-DOPA in the hu man ovarian follicular fluid acts as an antioxidant factor on granulosa cells
por: Blohberger, J., et al.
Publicado: (2016)

Arachidonic Acid in Follicular Fluid of PCOS Induces Oxidative Stress in a Human Ovarian Granulosa Tumor Cell Line (KGN) and Upregulates GDF15 Expression as a Response
por: Ma, Yalan, et al.
Publicado: (2022)

Corrigendum: Arachidonic acid in follicular fluid of PCOS induces oxidative stress in a human ovarian granulosa tumor cell line (KGN) and upregulates GDF15 expression as a response
por: Ma, Yalan, et al.
Publicado: (2022)

A rapid and robust method for the cryopreservation of human granulosa cells
por: Beschta, Sarah, et al.
Publicado: (2021)

1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells
por: Jiang, Yijie, et al.
Publicado: (2023)

Peroxisome Proliferator–Activated Receptor-γ Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-1, Aromatase, and Estradiol in Human Granulosa Cells
por: Kwintkiewicz, Jakub, et al.
Publicado: (2010)

Effect of Chemotherapeutics and Tocopherols on MCF-7 Breast Adenocarcinoma and KGN Ovarian Carcinoma Cell Lines In Vitro
por: Figueroa, Daniela, et al.
Publicado: (2019)

FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy
por: Wang, Rongli, et al.
Publicado: (2022)

Chitosan modified Fe(3)O(4)/KGN self-assembled nanoprobes for osteochondral MR diagnose and regeneration
por: Hong, Yuping, et al.
Publicado: (2020)

Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells
por: Ruan, Haonan, et al.
Publicado: (2022)

Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer
por: Beyer, Susanne, et al.
Publicado: (2020)

The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer
por: Chen, Fangfang, et al.
Publicado: (2021)

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells
por: Zhang, Yu, et al.
Publicado: (2010)

Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells
por: Zhang, Huibin, et al.
Publicado: (2023)

CircASPH promotes KGN cells proliferation through miR‐375/MAP2K6 axis in Polycystic Ovary Syndrome
por: Wu, Gengxiang, et al.
Publicado: (2020)

Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration
por: Chen, Chuyao, et al.
Publicado: (2022)

Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
por: Regan, Sheena L. P., et al.
Publicado: (2018)

MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis
por: Zhang, Jinbi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cj4hraa30ke9oa224qippvj9vu