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Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β

BACKGROUND: Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal ce...

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Detalles Bibliográficos
Autores principales: Goulart, Ernesto, de Caires-Junior, Luiz Carlos, Telles-Silva, Kayque Alves, Araujo, Bruno Henrique Silva, Kobayashi, Gerson S., Musso, Camila Manso, Assoni, Amanda Faria, Oliveira, Danyllo, Caldini, Elia, Gerstenhaber, Jonathan A., Raia, Silvano, Lelkes, Peter I., Zatz, Mayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694663/
https://www.ncbi.nlm.nih.gov/pubmed/31416480
http://dx.doi.org/10.1186/s13287-019-1367-x