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A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, which is associated with poor prognosis. Herceptin and other agents targeting HER2 have potent antitumor efficacy in patients with HER2-positive cancers. However, the development of drug resistance adve...

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Detalles Bibliográficos
Autores principales:	Yu, Shengnan, Zhang, Jing, Yan, Yongxiang, Yao, Xudong, Fang, Lijuan, Xiong, Hui, Liu, Yang, Chu, Qian, Zhou, Pengfei, Wu, Kongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694677/ https://www.ncbi.nlm.nih.gov/pubmed/31412896 http://dx.doi.org/10.1186/s13046-019-1354-1

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