Too Much Compromise in Today's CRISPR Pipelines

CRISPR-based editing is a revolutionary tool for genome engineering and discovery. The pace of innovation in this young field is truly astonishing, and yet significant gaps remain in the set of capabilities offered. In particular, scalable (massively parallel and multiplex) editing is only available...

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Detalles Bibliográficos
Autor principal: Fox, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694770/
https://www.ncbi.nlm.nih.gov/pubmed/31225751
http://dx.doi.org/10.1089/crispr.2019.0015
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author Fox, Richard
author_facet Fox, Richard
author_sort Fox, Richard
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description CRISPR-based editing is a revolutionary tool for genome engineering and discovery. The pace of innovation in this young field is truly astonishing, and yet significant gaps remain in the set of capabilities offered. In particular, scalable (massively parallel and multiplex) editing is only available for a small variety of edit types, placing fundamental limits on the kinds of studies researchers can perform. Additional advancements are needed to realize the full potential of the technology.
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spelling pubmed-66947702019-08-20 Too Much Compromise in Today's CRISPR Pipelines Fox, Richard CRISPR J Perspectives CRISPR-based editing is a revolutionary tool for genome engineering and discovery. The pace of innovation in this young field is truly astonishing, and yet significant gaps remain in the set of capabilities offered. In particular, scalable (massively parallel and multiplex) editing is only available for a small variety of edit types, placing fundamental limits on the kinds of studies researchers can perform. Additional advancements are needed to realize the full potential of the technology. Mary Ann Liebert, Inc., publishers 2019-06-01 2019-06-21 /pmc/articles/PMC6694770/ /pubmed/31225751 http://dx.doi.org/10.1089/crispr.2019.0015 Text en © Richard Fox 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Fox, Richard
Too Much Compromise in Today's CRISPR Pipelines
title Too Much Compromise in Today's CRISPR Pipelines
title_full Too Much Compromise in Today's CRISPR Pipelines
title_fullStr Too Much Compromise in Today's CRISPR Pipelines
title_full_unstemmed Too Much Compromise in Today's CRISPR Pipelines
title_short Too Much Compromise in Today's CRISPR Pipelines
title_sort too much compromise in today's crispr pipelines
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694770/
https://www.ncbi.nlm.nih.gov/pubmed/31225751
http://dx.doi.org/10.1089/crispr.2019.0015
work_keys_str_mv AT foxrichard toomuchcompromiseintodayscrisprpipelines

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