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Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus
OBJECTIVES: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. METHODS: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24–28 weeks o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taibah University
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694875/ https://www.ncbi.nlm.nih.gov/pubmed/31435260 http://dx.doi.org/10.1016/j.jtumed.2017.01.005 |
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author | Abu-Heija, Adel T. Al-Bash, Majeda R. Al-Kalbani, Moza A. |
author_facet | Abu-Heija, Adel T. Al-Bash, Majeda R. Al-Kalbani, Moza A. |
author_sort | Abu-Heija, Adel T. |
collection | PubMed |
description | OBJECTIVES: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. METHODS: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24–28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. RESULTS: This study screened 307 women and identified 83 (27.03%) OGCT-positive and 23 (7.5%) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0% to 2.2%, respectively, in women aged ≤25 years to 37.8% and 14.7%, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8% to 3.8%, respectively, in women with BMIs ≤25 kg/m(2) to 37.8% and 9.9%, respectively, in women with BMIs >25 kg/m(2) (p = 0.02 and p = 0.04, respectively). CONCLUSION: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM. |
format | Online Article Text |
id | pubmed-6694875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taibah University |
record_format | MEDLINE/PubMed |
spelling | pubmed-66948752019-08-21 Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus Abu-Heija, Adel T. Al-Bash, Majeda R. Al-Kalbani, Moza A. J Taibah Univ Med Sci Original Article OBJECTIVES: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. METHODS: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24–28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. RESULTS: This study screened 307 women and identified 83 (27.03%) OGCT-positive and 23 (7.5%) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0% to 2.2%, respectively, in women aged ≤25 years to 37.8% and 14.7%, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8% to 3.8%, respectively, in women with BMIs ≤25 kg/m(2) to 37.8% and 9.9%, respectively, in women with BMIs >25 kg/m(2) (p = 0.02 and p = 0.04, respectively). CONCLUSION: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM. Taibah University 2017-02-22 /pmc/articles/PMC6694875/ /pubmed/31435260 http://dx.doi.org/10.1016/j.jtumed.2017.01.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Abu-Heija, Adel T. Al-Bash, Majeda R. Al-Kalbani, Moza A. Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title | Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title_full | Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title_fullStr | Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title_full_unstemmed | Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title_short | Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
title_sort | effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694875/ https://www.ncbi.nlm.nih.gov/pubmed/31435260 http://dx.doi.org/10.1016/j.jtumed.2017.01.005 |
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