A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease remain poorly understood. In humans, elevated UA leve...

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Detalles Bibliográficos
Autores principales: Lang, Sven, Hilsabeck, Tyler A., Wilson, Kenneth A., Sharma, Amit, Bose, Neelanjan, Brackman, Deanna J., Beck, Jennifer N., Chen, Ling, Watson, Mark A., Killilea, David W., Ho, Sunita, Kahn, Arnold, Giacomini, Kathleen, Stoller, Marshall L., Chi, Thomas, Kapahi, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695094/
https://www.ncbi.nlm.nih.gov/pubmed/31415568
http://dx.doi.org/10.1371/journal.pgen.1008318

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