MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug

Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transf...

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Autores principales: Alfaro, Aline, León, Andrea, Guajardo-Correa, Emanuel, Reúquen, Patricia, Torres, Francisco, Mery, Mario, Segura, Rodrigo, Zapata, Paula A., Orihuela, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695098/
https://www.ncbi.nlm.nih.gov/pubmed/31415561
http://dx.doi.org/10.1371/journal.pone.0214900
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author Alfaro, Aline
León, Andrea
Guajardo-Correa, Emanuel
Reúquen, Patricia
Torres, Francisco
Mery, Mario
Segura, Rodrigo
Zapata, Paula A.
Orihuela, Pedro A.
author_facet Alfaro, Aline
León, Andrea
Guajardo-Correa, Emanuel
Reúquen, Patricia
Torres, Francisco
Mery, Mario
Segura, Rodrigo
Zapata, Paula A.
Orihuela, Pedro A.
author_sort Alfaro, Aline
collection PubMed
description Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy.
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spelling pubmed-66950982019-08-16 MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug Alfaro, Aline León, Andrea Guajardo-Correa, Emanuel Reúquen, Patricia Torres, Francisco Mery, Mario Segura, Rodrigo Zapata, Paula A. Orihuela, Pedro A. PLoS One Research Article Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy. Public Library of Science 2019-08-15 /pmc/articles/PMC6695098/ /pubmed/31415561 http://dx.doi.org/10.1371/journal.pone.0214900 Text en © 2019 Alfaro et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alfaro, Aline
León, Andrea
Guajardo-Correa, Emanuel
Reúquen, Patricia
Torres, Francisco
Mery, Mario
Segura, Rodrigo
Zapata, Paula A.
Orihuela, Pedro A.
MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title_full MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title_fullStr MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title_full_unstemmed MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title_short MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
title_sort mgo nanoparticles coated with polyethylene glycol as carrier for 2-methoxyestradiol anticancer drug
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695098/
https://www.ncbi.nlm.nih.gov/pubmed/31415561
http://dx.doi.org/10.1371/journal.pone.0214900
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