Cargando…

The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review

BACKGROUND: Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) have been described as promising alternatives to treat different pain syndromes. This study evaluated the effects of TMS and tDCS in the treatment of chronic orofacial pain, through a systematic re...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferreira, Natália R., Junqueira, Ygor N., Corrêa, Nathália B., Fonseca, Estevão O., Brito, Nathália B. M., Menezes, Thayná A., Magini, Márcio, Fidalgo, Tatiana K. S., Ferreira, Daniele M. T. P., de Lima, Rodrigo L., Carvalho, Antônio C., DosSantos, Marcos F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695170/
https://www.ncbi.nlm.nih.gov/pubmed/31415654
http://dx.doi.org/10.1371/journal.pone.0221110
_version_ 1783443985591697408
author Ferreira, Natália R.
Junqueira, Ygor N.
Corrêa, Nathália B.
Fonseca, Estevão O.
Brito, Nathália B. M.
Menezes, Thayná A.
Magini, Márcio
Fidalgo, Tatiana K. S.
Ferreira, Daniele M. T. P.
de Lima, Rodrigo L.
Carvalho, Antônio C.
DosSantos, Marcos F.
author_facet Ferreira, Natália R.
Junqueira, Ygor N.
Corrêa, Nathália B.
Fonseca, Estevão O.
Brito, Nathália B. M.
Menezes, Thayná A.
Magini, Márcio
Fidalgo, Tatiana K. S.
Ferreira, Daniele M. T. P.
de Lima, Rodrigo L.
Carvalho, Antônio C.
DosSantos, Marcos F.
author_sort Ferreira, Natália R.
collection PubMed
description BACKGROUND: Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) have been described as promising alternatives to treat different pain syndromes. This study evaluated the effects of TMS and tDCS in the treatment of chronic orofacial pain, through a systematic review. METHODS: An electronic search was performed in major databases: MEDLINE, Scopus, Web of Science, Cochrane, Embase, LILACS, BBO, Open Gray and CINAHL. The eligibility criteria comprised randomized clinical trials (RCTs) that applied TMS or tDCS to treat chronic orofacial pain. The variables analyzed were pain, functional limitation, quality of life, tolerance to treatment, somatosensory changes, and adverse effects. The risk of bias was assessed through the Cochrane Collaboration tool, and the certainty of evidence was evaluated through GRADE. The protocol was registered in the PROSPERO database (CRD42018090774). RESULTS: The electronic search resulted in 636 studies. Thereafter, the eligibility criteria were applied and the duplicates removed, resulting in eight RCTs (four TMS and four tDCS). The findings of these studies suggest that rTMS applied to the Motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC) and the secondary somatosensory cortex (S2) provide adequate orofacial pain relief. Two studies reported significant pain improvement with tDCS applied over M1 while the other two failed to demonstrate significant effects compared to placebo. CONCLUSIONS: rTMS, applied to M1, DLPFC or S2, is a promising approach for the treatment of chronic orofacial pain. Moreover, tDCS targeting M1 seems to be also effective in chronic orofacial pain treatment. The included studies used a wide variety of therapeutic protocols. In addition, most of them used small sample sizes, with a high risk of biases in their methodologies, thus producing a low quality of evidence. The results indicate that further research should be carried out with caution and with better-standardized therapeutic protocols.
format Online
Article
Text
id pubmed-6695170
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66951702019-08-16 The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review Ferreira, Natália R. Junqueira, Ygor N. Corrêa, Nathália B. Fonseca, Estevão O. Brito, Nathália B. M. Menezes, Thayná A. Magini, Márcio Fidalgo, Tatiana K. S. Ferreira, Daniele M. T. P. de Lima, Rodrigo L. Carvalho, Antônio C. DosSantos, Marcos F. PLoS One Research Article BACKGROUND: Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) have been described as promising alternatives to treat different pain syndromes. This study evaluated the effects of TMS and tDCS in the treatment of chronic orofacial pain, through a systematic review. METHODS: An electronic search was performed in major databases: MEDLINE, Scopus, Web of Science, Cochrane, Embase, LILACS, BBO, Open Gray and CINAHL. The eligibility criteria comprised randomized clinical trials (RCTs) that applied TMS or tDCS to treat chronic orofacial pain. The variables analyzed were pain, functional limitation, quality of life, tolerance to treatment, somatosensory changes, and adverse effects. The risk of bias was assessed through the Cochrane Collaboration tool, and the certainty of evidence was evaluated through GRADE. The protocol was registered in the PROSPERO database (CRD42018090774). RESULTS: The electronic search resulted in 636 studies. Thereafter, the eligibility criteria were applied and the duplicates removed, resulting in eight RCTs (four TMS and four tDCS). The findings of these studies suggest that rTMS applied to the Motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC) and the secondary somatosensory cortex (S2) provide adequate orofacial pain relief. Two studies reported significant pain improvement with tDCS applied over M1 while the other two failed to demonstrate significant effects compared to placebo. CONCLUSIONS: rTMS, applied to M1, DLPFC or S2, is a promising approach for the treatment of chronic orofacial pain. Moreover, tDCS targeting M1 seems to be also effective in chronic orofacial pain treatment. The included studies used a wide variety of therapeutic protocols. In addition, most of them used small sample sizes, with a high risk of biases in their methodologies, thus producing a low quality of evidence. The results indicate that further research should be carried out with caution and with better-standardized therapeutic protocols. Public Library of Science 2019-08-15 /pmc/articles/PMC6695170/ /pubmed/31415654 http://dx.doi.org/10.1371/journal.pone.0221110 Text en © 2019 Ferreira et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ferreira, Natália R.
Junqueira, Ygor N.
Corrêa, Nathália B.
Fonseca, Estevão O.
Brito, Nathália B. M.
Menezes, Thayná A.
Magini, Márcio
Fidalgo, Tatiana K. S.
Ferreira, Daniele M. T. P.
de Lima, Rodrigo L.
Carvalho, Antônio C.
DosSantos, Marcos F.
The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title_full The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title_fullStr The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title_full_unstemmed The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title_short The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
title_sort efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695170/
https://www.ncbi.nlm.nih.gov/pubmed/31415654
http://dx.doi.org/10.1371/journal.pone.0221110
work_keys_str_mv AT ferreiranataliar theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT junqueiraygorn theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT correanathaliab theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT fonsecaestevaoo theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT britonathaliabm theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT menezesthaynaa theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT maginimarcio theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT fidalgotatianaks theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT ferreiradanielemtp theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT delimarodrigol theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT carvalhoantonioc theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT dossantosmarcosf theefficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT ferreiranataliar efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT junqueiraygorn efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT correanathaliab efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT fonsecaestevaoo efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT britonathaliabm efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT menezesthaynaa efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT maginimarcio efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT fidalgotatianaks efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT ferreiradanielemtp efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT delimarodrigol efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT carvalhoantonioc efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview
AT dossantosmarcosf efficacyoftranscranialdirectcurrentstimulationandtranscranialmagneticstimulationforchronicorofacialpainasystematicreview