Prospective evaluation of two screening methods for molecular testing of metastatic melanoma: Diagnostic performance of BRAF V600E immunohistochemistry and of a NRAS-BRAF fully automated real-time PCR-based assay

Screening for theranostic biomarkers is mandatory for the therapeutic management of cutaneous melanoma. BRAF and NRAS genes must be tested in routine clinical practice. The methods used to identify these alterations must be sensitive to detect mutant alleles in a background of wild type alleles, and...

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Detalles Bibliográficos
Autores principales: Vallée, Audrey, Denis-Musquer, Marie, Herbreteau, Guillaume, Théoleyre, Sandrine, Bossard, Céline, Denis, Marc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695223/
https://www.ncbi.nlm.nih.gov/pubmed/31415669
http://dx.doi.org/10.1371/journal.pone.0221123

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