Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation

A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldberg, Madeline, Malik, Khizar, Jiswant, Rekha, Khaku, Aunali S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695239/
https://www.ncbi.nlm.nih.gov/pubmed/31431841
http://dx.doi.org/10.7759/cureus.4936
_version_ 1783444002116206592
author Goldberg, Madeline
Malik, Khizar
Jiswant, Rekha
Khaku, Aunali S
author_facet Goldberg, Madeline
Malik, Khizar
Jiswant, Rekha
Khaku, Aunali S
author_sort Goldberg, Madeline
collection PubMed
description A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme.
format Online
Article
Text
id pubmed-6695239
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-66952392019-08-20 Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation Goldberg, Madeline Malik, Khizar Jiswant, Rekha Khaku, Aunali S Cureus Neurology A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme. Cureus 2019-06-18 /pmc/articles/PMC6695239/ /pubmed/31431841 http://dx.doi.org/10.7759/cureus.4936 Text en Copyright © 2019, Goldberg et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Goldberg, Madeline
Malik, Khizar
Jiswant, Rekha
Khaku, Aunali S
Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title_full Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title_fullStr Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title_full_unstemmed Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title_short Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
title_sort eye-of-the-tiger sign in neurodegeneration with brain iron accumulation
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695239/
https://www.ncbi.nlm.nih.gov/pubmed/31431841
http://dx.doi.org/10.7759/cureus.4936
work_keys_str_mv AT goldbergmadeline eyeofthetigersigninneurodegenerationwithbrainironaccumulation
AT malikkhizar eyeofthetigersigninneurodegenerationwithbrainironaccumulation
AT jiswantrekha eyeofthetigersigninneurodegenerationwithbrainironaccumulation
AT khakuaunalis eyeofthetigersigninneurodegenerationwithbrainironaccumulation

Ejemplares similares