Deletion of Apoptosis Inhibitor F1L in Vaccinia Virus Increases Safety and Oncolysis for Cancer Therapy

Vaccinia virus (VACV) possesses a great safety record as a smallpox vaccine and has been intensively used as an oncolytic virus against various types of cancer over the past decade. Different strategies were developed to make VACV safe and selective to cancer cells. Leading clinical candidates, such...

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Detalles Bibliográficos
Autores principales: Pelin, Adrian, Foloppe, Johann, Petryk, Julia, Singaravelu, Ragunath, Hussein, Marian, Gossart, Florian, Jennings, Victoria A., Stubbert, Lawton J., Foster, Madison, Storbeck, Christopher, Postigo, Antonio, Scut, Elena, Laight, Brian, Way, Michael, Erbs, Philippe, Le Boeuf, Fabrice, Bell, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695278/
https://www.ncbi.nlm.nih.gov/pubmed/31428674
http://dx.doi.org/10.1016/j.omto.2019.06.004

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