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Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans
RATIONALE: Methamphetamine (MA) use is steadily increasing and thus constitutes a major public health concern. Women seem to be particularly vulnerable to developing MA use disorder, as they initiate use at a younger age and transition more quickly to problematic use. Initial drug responses may pred...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695366/ https://www.ncbi.nlm.nih.gov/pubmed/31165207 http://dx.doi.org/10.1007/s00213-019-05276-2 |
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author | Mayo, Leah M. Paul, Elisabeth DeArcangelis, Jessica Van Hedger, Kathryne de Wit, Harriet |
author_facet | Mayo, Leah M. Paul, Elisabeth DeArcangelis, Jessica Van Hedger, Kathryne de Wit, Harriet |
author_sort | Mayo, Leah M. |
collection | PubMed |
description | RATIONALE: Methamphetamine (MA) use is steadily increasing and thus constitutes a major public health concern. Women seem to be particularly vulnerable to developing MA use disorder, as they initiate use at a younger age and transition more quickly to problematic use. Initial drug responses may predict subsequent use, but little information exists on potential gender differences in the acute effects of MA prior to dependence. OBJECTIVE: We examined gender differences in the acute effects of MA on subjective mood and reward-related behavior in healthy, non-dependent humans. METHODS: Men (n = 44) and women (n = 29) completed 4 sessions in which they received placebo or MA under double-blind conditions twice each. During peak drug effect, participants completed the monetary incentive delay task to assess reaction times to cues signaling potential monetary losses or gains, in an effort to determine if MA would potentiate reward-motivated behavior. Cardiovascular and subjective drug effects were assessed throughout sessions. RESULTS: Overall, participants responded more quickly to cues predicting incentivized trials, particularly large-magnitude incentives, than to cues predicting no incentive. MA produced faster reaction times in women, but not in men. MA produced typical stimulant-like subjective and cardiovascular effects in all participants, but subjective ratings of vigor and (reduced) sedation were greater in women than in men. CONCLUSIONS: Women appear to be more sensitive to the psychomotor-related behavioral and subjective effects of MA. These findings provide initial insight into gender differences in acute effects of MA that may contribute to gender differences in problematic MA use. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-019-05276-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6695366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-66953662019-08-28 Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans Mayo, Leah M. Paul, Elisabeth DeArcangelis, Jessica Van Hedger, Kathryne de Wit, Harriet Psychopharmacology (Berl) Original Investigation RATIONALE: Methamphetamine (MA) use is steadily increasing and thus constitutes a major public health concern. Women seem to be particularly vulnerable to developing MA use disorder, as they initiate use at a younger age and transition more quickly to problematic use. Initial drug responses may predict subsequent use, but little information exists on potential gender differences in the acute effects of MA prior to dependence. OBJECTIVE: We examined gender differences in the acute effects of MA on subjective mood and reward-related behavior in healthy, non-dependent humans. METHODS: Men (n = 44) and women (n = 29) completed 4 sessions in which they received placebo or MA under double-blind conditions twice each. During peak drug effect, participants completed the monetary incentive delay task to assess reaction times to cues signaling potential monetary losses or gains, in an effort to determine if MA would potentiate reward-motivated behavior. Cardiovascular and subjective drug effects were assessed throughout sessions. RESULTS: Overall, participants responded more quickly to cues predicting incentivized trials, particularly large-magnitude incentives, than to cues predicting no incentive. MA produced faster reaction times in women, but not in men. MA produced typical stimulant-like subjective and cardiovascular effects in all participants, but subjective ratings of vigor and (reduced) sedation were greater in women than in men. CONCLUSIONS: Women appear to be more sensitive to the psychomotor-related behavioral and subjective effects of MA. These findings provide initial insight into gender differences in acute effects of MA that may contribute to gender differences in problematic MA use. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-019-05276-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-06-05 2019 /pmc/articles/PMC6695366/ /pubmed/31165207 http://dx.doi.org/10.1007/s00213-019-05276-2 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Investigation Mayo, Leah M. Paul, Elisabeth DeArcangelis, Jessica Van Hedger, Kathryne de Wit, Harriet Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title | Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title_full | Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title_fullStr | Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title_full_unstemmed | Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title_short | Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
title_sort | gender differences in the behavioral and subjective effects of methamphetamine in healthy humans |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695366/ https://www.ncbi.nlm.nih.gov/pubmed/31165207 http://dx.doi.org/10.1007/s00213-019-05276-2 |
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