Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease, with no known genetic cause to date. Oligodendroglial α-synuclein accumulation, neuroinflammation, and early myelin dysfunction are hallmark features of the disease and have been modeled in part in various preclinical model...

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Detalles Bibliográficos
Autores principales: Ndayisaba, Alain, Herrera-Vaquero, Marcos, Wenning, Gregor K., Stefanova, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695370/
https://www.ncbi.nlm.nih.gov/pubmed/31187309
http://dx.doi.org/10.1007/s10286-019-00614-y
Descripción
Sumario:Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease, with no known genetic cause to date. Oligodendroglial α-synuclein accumulation, neuroinflammation, and early myelin dysfunction are hallmark features of the disease and have been modeled in part in various preclinical models of MSA, yet the pathophysiology of MSA remains elusive. Here, we review the role and scientific challenges of induced pluripotent stem cells in the detection of novel biomarkers and druggable targets in MSA.

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