Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease, with no known genetic cause to date. Oligodendroglial α-synuclein accumulation, neuroinflammation, and early myelin dysfunction are hallmark features of the disease and have been modeled in part in various preclinical model...

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Autores principales: Ndayisaba, Alain, Herrera-Vaquero, Marcos, Wenning, Gregor K., Stefanova, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695370/
https://www.ncbi.nlm.nih.gov/pubmed/31187309
http://dx.doi.org/10.1007/s10286-019-00614-y
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author Ndayisaba, Alain
Herrera-Vaquero, Marcos
Wenning, Gregor K.
Stefanova, Nadia
author_facet Ndayisaba, Alain
Herrera-Vaquero, Marcos
Wenning, Gregor K.
Stefanova, Nadia
author_sort Ndayisaba, Alain
collection PubMed
description Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease, with no known genetic cause to date. Oligodendroglial α-synuclein accumulation, neuroinflammation, and early myelin dysfunction are hallmark features of the disease and have been modeled in part in various preclinical models of MSA, yet the pathophysiology of MSA remains elusive. Here, we review the role and scientific challenges of induced pluripotent stem cells in the detection of novel biomarkers and druggable targets in MSA.
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spelling pubmed-66953702019-08-28 Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges Ndayisaba, Alain Herrera-Vaquero, Marcos Wenning, Gregor K. Stefanova, Nadia Clin Auton Res Review Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease, with no known genetic cause to date. Oligodendroglial α-synuclein accumulation, neuroinflammation, and early myelin dysfunction are hallmark features of the disease and have been modeled in part in various preclinical models of MSA, yet the pathophysiology of MSA remains elusive. Here, we review the role and scientific challenges of induced pluripotent stem cells in the detection of novel biomarkers and druggable targets in MSA. Springer Berlin Heidelberg 2019-06-11 2019 /pmc/articles/PMC6695370/ /pubmed/31187309 http://dx.doi.org/10.1007/s10286-019-00614-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Ndayisaba, Alain
Herrera-Vaquero, Marcos
Wenning, Gregor K.
Stefanova, Nadia
Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title_full Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title_fullStr Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title_full_unstemmed Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title_short Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
title_sort induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695370/
https://www.ncbi.nlm.nih.gov/pubmed/31187309
http://dx.doi.org/10.1007/s10286-019-00614-y
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