Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence

RATIONALE: Dopamine D2-like receptors (D2R) are important drug targets in schizophrenia and Parkinson’s disease, but D2R ligands also cause cognitive inflexibility such as poor reversal learning. The specific role of D2R in reversal learning remains unclear. OBJECTIVES: We tested the hypotheses that...

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Detalles Bibliográficos
Autores principales: Alsiö, Johan, Phillips, Benjamin U., Sala-Bayo, Júlia, Nilsson, Simon R. O., Calafat-Pla, Teresa C., Rizwand, Arazo, Plumbridge, Jessica M., López-Cruz, Laura, Dalley, Jeffrey W., Cardinal, Rudolf N., Mar, Adam C., Robbins, Trevor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695374/
https://www.ncbi.nlm.nih.gov/pubmed/31218428
http://dx.doi.org/10.1007/s00213-019-05296-y

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