Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons

Donepezil, a therapeutic drug for Alzheimer’s disease, ameliorates cognitive dysfunction through selective inhibition of acetylcholinesterase. However, recent studies have also reported off-target effects of donepezil that likely contribute to its therapeutic effects. In this study, we investigated...

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Detalles Bibliográficos
Autores principales: Takada-Takatori, Yuki, Nakagawa, Shota, Kimata, Riko, Nao, Yousuke, Mizukawa, Yumiko, Urushidani, Tetsuro, Izumi, Yasuhiko, Akaike, Akinori, Tsuchida, Katsuharu, Kume, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695423/
https://www.ncbi.nlm.nih.gov/pubmed/31417133
http://dx.doi.org/10.1038/s41598-019-47462-4

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