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Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons
Donepezil, a therapeutic drug for Alzheimer’s disease, ameliorates cognitive dysfunction through selective inhibition of acetylcholinesterase. However, recent studies have also reported off-target effects of donepezil that likely contribute to its therapeutic effects. In this study, we investigated...
Autores principales: | Takada-Takatori, Yuki, Nakagawa, Shota, Kimata, Riko, Nao, Yousuke, Mizukawa, Yumiko, Urushidani, Tetsuro, Izumi, Yasuhiko, Akaike, Akinori, Tsuchida, Katsuharu, Kume, Toshiaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695423/ https://www.ncbi.nlm.nih.gov/pubmed/31417133 http://dx.doi.org/10.1038/s41598-019-47462-4 |
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