EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Accurate DNA replication is essential to preserve genomic integrity and prevent chromosomal instability-associated diseases including cancer. Key to this process is the cells’ ability to stabilize and restart stalled replication forks. Here, we show that the EXD2 nuclease is essential to this proces...

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Detalles Bibliográficos
Autores principales: Nieminuszczy, Jadwiga, Broderick, Ronan, Bellani, Marina A., Smethurst, Elizabeth, Schwab, Rebekka A., Cherdyntseva, Veronica, Evmorfopoulou, Theodora, Lin, Yea-Lih, Minczuk, Michal, Pasero, Philippe, Gagos, Sarantis, Seidman, Michael M., Niedzwiedz, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695479/
https://www.ncbi.nlm.nih.gov/pubmed/31255466
http://dx.doi.org/10.1016/j.molcel.2019.05.026

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