Extrahepatic hepcidin production: The intriguing outcomes of recent years

Hepcidin is the hyposideremic hormone regulating iron metabolism. It is a defensin-like disulfide-bonded peptide with antimicrobial activity. The main site of hepcidin production is the liver where its synthesis is modulated by iron, inflammation and erythropoietic signaling. However, hepcidin local...

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Autores principales: Daher, Raêd, Lefebvre, Thibaud, Puy, Hervé, Karim, Zoubida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695539/
https://www.ncbi.nlm.nih.gov/pubmed/31423425
http://dx.doi.org/10.12998/wjcc.v7.i15.1926
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author Daher, Raêd
Lefebvre, Thibaud
Puy, Hervé
Karim, Zoubida
author_facet Daher, Raêd
Lefebvre, Thibaud
Puy, Hervé
Karim, Zoubida
author_sort Daher, Raêd
collection PubMed
description Hepcidin is the hyposideremic hormone regulating iron metabolism. It is a defensin-like disulfide-bonded peptide with antimicrobial activity. The main site of hepcidin production is the liver where its synthesis is modulated by iron, inflammation and erythropoietic signaling. However, hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these organs. This review highlights the presence of peripheral hepcidin and its potential functions. Understanding the role of extrahepatic hepcidin could be of great physiological and therapeutic importance for several specific pathologies.
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spelling pubmed-66955392019-08-16 Extrahepatic hepcidin production: The intriguing outcomes of recent years Daher, Raêd Lefebvre, Thibaud Puy, Hervé Karim, Zoubida World J Clin Cases Minireviews Hepcidin is the hyposideremic hormone regulating iron metabolism. It is a defensin-like disulfide-bonded peptide with antimicrobial activity. The main site of hepcidin production is the liver where its synthesis is modulated by iron, inflammation and erythropoietic signaling. However, hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these organs. This review highlights the presence of peripheral hepcidin and its potential functions. Understanding the role of extrahepatic hepcidin could be of great physiological and therapeutic importance for several specific pathologies. Baishideng Publishing Group Inc 2019-08-06 2019-08-06 /pmc/articles/PMC6695539/ /pubmed/31423425 http://dx.doi.org/10.12998/wjcc.v7.i15.1926 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Daher, Raêd
Lefebvre, Thibaud
Puy, Hervé
Karim, Zoubida
Extrahepatic hepcidin production: The intriguing outcomes of recent years
title Extrahepatic hepcidin production: The intriguing outcomes of recent years
title_full Extrahepatic hepcidin production: The intriguing outcomes of recent years
title_fullStr Extrahepatic hepcidin production: The intriguing outcomes of recent years
title_full_unstemmed Extrahepatic hepcidin production: The intriguing outcomes of recent years
title_short Extrahepatic hepcidin production: The intriguing outcomes of recent years
title_sort extrahepatic hepcidin production: the intriguing outcomes of recent years
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695539/
https://www.ncbi.nlm.nih.gov/pubmed/31423425
http://dx.doi.org/10.12998/wjcc.v7.i15.1926
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