Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are progressive and fatal neurodegenerative disorders showing mislocalization and cytosolic accumulation of TDP-43 inclusions in the central nervous system. The decrease in the efficiency of the clearance systems in agi...

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Detalles Bibliográficos
Autores principales: Cascella, Roberta, Fani, Giulia, Bigi, Alessandra, Chiti, Fabrizio, Cecchi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695586/
https://www.ncbi.nlm.nih.gov/pubmed/31357627
http://dx.doi.org/10.3390/ijms20153685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695586/
https://www.ncbi.nlm.nih.gov/pubmed/31357627
http://dx.doi.org/10.3390/ijms20153685

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