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Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

Hydrogen peroxide (H(2)O(2)), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes. Depending on its spatiotemporal accumulation profile, this molecule may act as a signa...

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Autores principales: Lismont, Celien, Revenco, Iulia, Fransen, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695606/
https://www.ncbi.nlm.nih.gov/pubmed/31357514
http://dx.doi.org/10.3390/ijms20153673
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author Lismont, Celien
Revenco, Iulia
Fransen, Marc
author_facet Lismont, Celien
Revenco, Iulia
Fransen, Marc
author_sort Lismont, Celien
collection PubMed
description Hydrogen peroxide (H(2)O(2)), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes. Depending on its spatiotemporal accumulation profile, this molecule may act as a signaling messenger or cause oxidative damage. The focus of this review is to comprehensively evaluate the evidence that peroxisomes, organelles best known for their role in cellular lipid metabolism, also serve as hubs in the H(2)O(2) signaling network. We first briefly introduce the basic concepts of how H(2)O(2) can drive cellular signaling events. Next, we outline the peroxisomal enzyme systems involved in H(2)O(2) metabolism in mammals and reflect on how this oxidant can permeate across the organellar membrane. In addition, we provide an up-to-date overview of molecular targets and biological processes that can be affected by changes in peroxisomal H(2)O(2) metabolism. Where possible, emphasis is placed on the molecular mechanisms and factors involved. From the data presented, it is clear that there are still numerous gaps in our knowledge. Therefore, gaining more insight into how peroxisomes are integrated in the cellular H(2)O(2) signaling network is of key importance to unravel the precise role of peroxisomal H(2)O(2) production and scavenging in normal and pathological conditions.
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spelling pubmed-66956062019-09-05 Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease Lismont, Celien Revenco, Iulia Fransen, Marc Int J Mol Sci Review Hydrogen peroxide (H(2)O(2)), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes. Depending on its spatiotemporal accumulation profile, this molecule may act as a signaling messenger or cause oxidative damage. The focus of this review is to comprehensively evaluate the evidence that peroxisomes, organelles best known for their role in cellular lipid metabolism, also serve as hubs in the H(2)O(2) signaling network. We first briefly introduce the basic concepts of how H(2)O(2) can drive cellular signaling events. Next, we outline the peroxisomal enzyme systems involved in H(2)O(2) metabolism in mammals and reflect on how this oxidant can permeate across the organellar membrane. In addition, we provide an up-to-date overview of molecular targets and biological processes that can be affected by changes in peroxisomal H(2)O(2) metabolism. Where possible, emphasis is placed on the molecular mechanisms and factors involved. From the data presented, it is clear that there are still numerous gaps in our knowledge. Therefore, gaining more insight into how peroxisomes are integrated in the cellular H(2)O(2) signaling network is of key importance to unravel the precise role of peroxisomal H(2)O(2) production and scavenging in normal and pathological conditions. MDPI 2019-07-26 /pmc/articles/PMC6695606/ /pubmed/31357514 http://dx.doi.org/10.3390/ijms20153673 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lismont, Celien
Revenco, Iulia
Fransen, Marc
Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title_full Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title_fullStr Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title_full_unstemmed Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title_short Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
title_sort peroxisomal hydrogen peroxide metabolism and signaling in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695606/
https://www.ncbi.nlm.nih.gov/pubmed/31357514
http://dx.doi.org/10.3390/ijms20153673
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