Cargando…

Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?

In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen a...

Descripción completa

Detalles Bibliográficos
Autores principales: Marquardt, Ryan M., Kim, Tae Hoon, Shin, Jung-Ho, Jeong, Jae-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695957/
https://www.ncbi.nlm.nih.gov/pubmed/31387263
http://dx.doi.org/10.3390/ijms20153822
_version_ 1783444156887072768
author Marquardt, Ryan M.
Kim, Tae Hoon
Shin, Jung-Ho
Jeong, Jae-Wook
author_facet Marquardt, Ryan M.
Kim, Tae Hoon
Shin, Jung-Ho
Jeong, Jae-Wook
author_sort Marquardt, Ryan M.
collection PubMed
description In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen act primarily through their cognate receptors to set off cascades of signaling pathways and enact large-scale gene expression programs. In endometriosis, when endometrial tissue grows outside the uterine cavity, progesterone and estrogen signaling are disrupted, commonly resulting in progesterone resistance and estrogen dominance. This hormone imbalance leads to heightened inflammation and may also increase the pelvic pain of the disease and decrease endometrial receptivity to embryo implantation. This review focuses on the molecular mechanisms governing progesterone and estrogen signaling supporting endometrial function and how they become dysregulated in endometriosis. Understanding how these mechanisms contribute to the pelvic pain and infertility associated with endometriosis will open new avenues of targeted medical therapies to give relief to the millions of women suffering its effects.
format Online
Article
Text
id pubmed-6695957
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66959572019-09-05 Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Marquardt, Ryan M. Kim, Tae Hoon Shin, Jung-Ho Jeong, Jae-Wook Int J Mol Sci Review In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen act primarily through their cognate receptors to set off cascades of signaling pathways and enact large-scale gene expression programs. In endometriosis, when endometrial tissue grows outside the uterine cavity, progesterone and estrogen signaling are disrupted, commonly resulting in progesterone resistance and estrogen dominance. This hormone imbalance leads to heightened inflammation and may also increase the pelvic pain of the disease and decrease endometrial receptivity to embryo implantation. This review focuses on the molecular mechanisms governing progesterone and estrogen signaling supporting endometrial function and how they become dysregulated in endometriosis. Understanding how these mechanisms contribute to the pelvic pain and infertility associated with endometriosis will open new avenues of targeted medical therapies to give relief to the millions of women suffering its effects. MDPI 2019-08-05 /pmc/articles/PMC6695957/ /pubmed/31387263 http://dx.doi.org/10.3390/ijms20153822 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marquardt, Ryan M.
Kim, Tae Hoon
Shin, Jung-Ho
Jeong, Jae-Wook
Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title_full Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title_fullStr Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title_full_unstemmed Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title_short Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
title_sort progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695957/
https://www.ncbi.nlm.nih.gov/pubmed/31387263
http://dx.doi.org/10.3390/ijms20153822
work_keys_str_mv AT marquardtryanm progesteroneandestrogensignalingintheendometriumwhatgoeswronginendometriosis
AT kimtaehoon progesteroneandestrogensignalingintheendometriumwhatgoeswronginendometriosis
AT shinjungho progesteroneandestrogensignalingintheendometriumwhatgoeswronginendometriosis
AT jeongjaewook progesteroneandestrogensignalingintheendometriumwhatgoeswronginendometriosis