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Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695957/ https://www.ncbi.nlm.nih.gov/pubmed/31387263 http://dx.doi.org/10.3390/ijms20153822 |
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author | Marquardt, Ryan M. Kim, Tae Hoon Shin, Jung-Ho Jeong, Jae-Wook |
author_facet | Marquardt, Ryan M. Kim, Tae Hoon Shin, Jung-Ho Jeong, Jae-Wook |
author_sort | Marquardt, Ryan M. |
collection | PubMed |
description | In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen act primarily through their cognate receptors to set off cascades of signaling pathways and enact large-scale gene expression programs. In endometriosis, when endometrial tissue grows outside the uterine cavity, progesterone and estrogen signaling are disrupted, commonly resulting in progesterone resistance and estrogen dominance. This hormone imbalance leads to heightened inflammation and may also increase the pelvic pain of the disease and decrease endometrial receptivity to embryo implantation. This review focuses on the molecular mechanisms governing progesterone and estrogen signaling supporting endometrial function and how they become dysregulated in endometriosis. Understanding how these mechanisms contribute to the pelvic pain and infertility associated with endometriosis will open new avenues of targeted medical therapies to give relief to the millions of women suffering its effects. |
format | Online Article Text |
id | pubmed-6695957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66959572019-09-05 Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Marquardt, Ryan M. Kim, Tae Hoon Shin, Jung-Ho Jeong, Jae-Wook Int J Mol Sci Review In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen act primarily through their cognate receptors to set off cascades of signaling pathways and enact large-scale gene expression programs. In endometriosis, when endometrial tissue grows outside the uterine cavity, progesterone and estrogen signaling are disrupted, commonly resulting in progesterone resistance and estrogen dominance. This hormone imbalance leads to heightened inflammation and may also increase the pelvic pain of the disease and decrease endometrial receptivity to embryo implantation. This review focuses on the molecular mechanisms governing progesterone and estrogen signaling supporting endometrial function and how they become dysregulated in endometriosis. Understanding how these mechanisms contribute to the pelvic pain and infertility associated with endometriosis will open new avenues of targeted medical therapies to give relief to the millions of women suffering its effects. MDPI 2019-08-05 /pmc/articles/PMC6695957/ /pubmed/31387263 http://dx.doi.org/10.3390/ijms20153822 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marquardt, Ryan M. Kim, Tae Hoon Shin, Jung-Ho Jeong, Jae-Wook Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title | Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title_full | Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title_fullStr | Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title_full_unstemmed | Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title_short | Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? |
title_sort | progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695957/ https://www.ncbi.nlm.nih.gov/pubmed/31387263 http://dx.doi.org/10.3390/ijms20153822 |
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