Cargando…

The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Girolami, Ilaria, Veronese, Nicola, Smith, Lee, Caruso, Maria G., Reddavide, Rosa, Leandro, Gioacchino, Demurtas, Jacopo, Nottegar, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695973/ https://www.ncbi.nlm.nih.gov/pubmed/31387321 http://dx.doi.org/10.3390/ijms20153831

Ejemplares similares

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis
por: Lawlor, Rita T., et al.
Publicado: (2019)

Prognostic Role of High-Grade Tumor Budding in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis with a Focus on Epithelial to Mesenchymal Transition
por: Lawlor, Rita T., et al.
Publicado: (2019)

Non-Alcoholic Fatty Liver Disease Is Associated with Higher Metabolic Expenditure in Overweight and Obese Subjects: A Case-Control Study
por: Reddavide, Rosa, et al.
Publicado: (2019)

The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study
por: Bolzetta, Francesco, et al.
Publicado: (2019)

Coffee Intake and Liver Steatosis: A Population Study in a Mediterranean Area
por: Veronese, Nicola, et al.
Publicado: (2018)

Fatty liver and mortality: a cohort population study in South Italy
por: Caruso, Maria Gabriella, et al.
Publicado: (2019)

Nutrition and lipidomic profile in colorectal cancers
por: Maria, Notarnicola, et al.
Publicado: (2018)

Bone marrow-derived extracellular vesicles carry the TGF-β signal transducer Smad2 to preserve hematopoietic stem cells in mice
por: Gautheron, Flavie, et al.
Publicado: (2023)

CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
por: Lawlor, Rita T., et al.
Publicado: (2018)

The role of diet in the prevention and treatment of Inflammatory Bowel Diseases
por: Rosa, Reddavide, et al.
Publicado: (2018)

Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
por: Veronese, Nicola, et al.
Publicado: (2021)

Mitochondrial genetic haplogroups and cardiovascular diseases: Data from the Osteoarthritis Initiative
por: Veronese, Nicola, et al.
Publicado: (2019)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

SMAD-Independent Down-Regulation of Caveolin-1 by TGF-β: Effects on Proliferation and Survival of Myofibroblasts
por: Sanders, Yan Y., et al.
Publicado: (2015)

Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: A systematic review and meta-analysis
por: Veronese, Nicola, et al.
Publicado: (2021)

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
por: Hernández-Aquino, Erika, et al.
Publicado: (2017)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis
por: Ruter, Dana L., et al.
Publicado: (2021)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

Clinical approach to the patient with acute gastrointestinal bleeding
por: Federica, Gaiani, et al.
Publicado: (2018)

Aggravation of TGFβ1-Smad Pathway and Autoimmune Myocarditis by Fungicide (Tebuconazole) Exposure
por: Marino, Ylenia, et al.
Publicado: (2023)

Glucosamine sulphate: an umbrella review of health outcomes
por: Veronese, Nicola, et al.
Publicado: (2020)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway
por: Kang, Heeseog, et al.
Publicado: (2020)

TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts
por: Wang, Junhua, et al.
Publicado: (2013)

Urinary incontinence and quality of life: a systematic review and meta-analysis
por: Pizzol, Damiano, et al.
Publicado: (2020)

Patient safety culture in Italian out-of-hours primary care service: a national cross-sectional survey study
por: Demurtas, Jacopo, et al.
Publicado: (2020)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Roles of TGFβ signaling Smads in squamous cell carcinoma
por: Han, Gangwen, et al.
Publicado: (2011)

Non-degradative ubiquitination in Smad-dependent TGF-β signaling
por: Tang, Liu-Ya, et al.
Publicado: (2011)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
por: Xie, Feng, et al.
Publicado: (2014)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
por: Hiew, Lih-Fhung, et al.
Publicado: (2021)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_f86etit6ta0f5nbuue6f4c696t