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Thyroid Hormones in Conventional and Organic Farmers in Thailand

Pesticides can act as endocrine disruptors by different mechanisms including inhibition of iodine absorption, increases in thyroid hormone clearance, decreased cellular uptake of thyroid hormones, or changes in expression of thyroid hormone regulated genes. This study examined how exposure to pestic...

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Autores principales: Kongtip, Pornpimol, Nankongnab, Noppanun, Kallayanatham, Nichcha, Pundee, Ritthirong, Choochouy, Nattagorn, Yimsabai, Jutharak, Woskie, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695996/
https://www.ncbi.nlm.nih.gov/pubmed/31362416
http://dx.doi.org/10.3390/ijerph16152704
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author Kongtip, Pornpimol
Nankongnab, Noppanun
Kallayanatham, Nichcha
Pundee, Ritthirong
Choochouy, Nattagorn
Yimsabai, Jutharak
Woskie, Susan
author_facet Kongtip, Pornpimol
Nankongnab, Noppanun
Kallayanatham, Nichcha
Pundee, Ritthirong
Choochouy, Nattagorn
Yimsabai, Jutharak
Woskie, Susan
author_sort Kongtip, Pornpimol
collection PubMed
description Pesticides can act as endocrine disruptors by different mechanisms including inhibition of iodine absorption, increases in thyroid hormone clearance, decreased cellular uptake of thyroid hormones, or changes in expression of thyroid hormone regulated genes. This study examined how exposure to pesticides impacts thyroid hormone levels, thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4) by comparing conventional (n = 195) and organic farmers (n = 222), and by evaluating which types of pesticides might be associated with changes in thyroid hormone levels. Questionnaires were used to collect information about farmer characteristics, self-reported stress, agricultural activities, and history of pesticide use. Conventional farmers were asked to report the type and quantity of pesticides used each day. The TSH, FT3, T3, and T4 levels of conventional farmers were 1.6, 1.2, 1.3, and 1.1 times higher than those of organic farmers, respectively, after adjusting for covariates. Several specific herbicides had a significant relationship between the amount applied and an increase in thyroid hormone levels, after covariate adjustment. They included: paraquat (TSH, FT3 and T3); acetochlor (FT4); atrazine (TSH, FT3 and T3); glyphosate (T4); diuron (TSH) and the “other” herbicides including alachlor, propanil, and butachlor (FT4 and T3). The most commonly used herbicide among conventional farmers was glyphosate, followed by paraquat, 2,4-dichlorophenoxyacetic acid (2,4-D). These findings suggest that exposure to pesticides could impact the development of metabolic diseases and other health outcomes by altering the endocrine system (the thyroid hormone levels) through the hypothalamic–pituitary–thyroid (HPT) axis. This work is a part of a longitudinal study which will evaluate the sub-chronic effects of repeated exposure to different types of pesticides on thyroid hormone levels.
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spelling pubmed-66959962019-09-05 Thyroid Hormones in Conventional and Organic Farmers in Thailand Kongtip, Pornpimol Nankongnab, Noppanun Kallayanatham, Nichcha Pundee, Ritthirong Choochouy, Nattagorn Yimsabai, Jutharak Woskie, Susan Int J Environ Res Public Health Article Pesticides can act as endocrine disruptors by different mechanisms including inhibition of iodine absorption, increases in thyroid hormone clearance, decreased cellular uptake of thyroid hormones, or changes in expression of thyroid hormone regulated genes. This study examined how exposure to pesticides impacts thyroid hormone levels, thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4) by comparing conventional (n = 195) and organic farmers (n = 222), and by evaluating which types of pesticides might be associated with changes in thyroid hormone levels. Questionnaires were used to collect information about farmer characteristics, self-reported stress, agricultural activities, and history of pesticide use. Conventional farmers were asked to report the type and quantity of pesticides used each day. The TSH, FT3, T3, and T4 levels of conventional farmers were 1.6, 1.2, 1.3, and 1.1 times higher than those of organic farmers, respectively, after adjusting for covariates. Several specific herbicides had a significant relationship between the amount applied and an increase in thyroid hormone levels, after covariate adjustment. They included: paraquat (TSH, FT3 and T3); acetochlor (FT4); atrazine (TSH, FT3 and T3); glyphosate (T4); diuron (TSH) and the “other” herbicides including alachlor, propanil, and butachlor (FT4 and T3). The most commonly used herbicide among conventional farmers was glyphosate, followed by paraquat, 2,4-dichlorophenoxyacetic acid (2,4-D). These findings suggest that exposure to pesticides could impact the development of metabolic diseases and other health outcomes by altering the endocrine system (the thyroid hormone levels) through the hypothalamic–pituitary–thyroid (HPT) axis. This work is a part of a longitudinal study which will evaluate the sub-chronic effects of repeated exposure to different types of pesticides on thyroid hormone levels. MDPI 2019-07-29 2019-08 /pmc/articles/PMC6695996/ /pubmed/31362416 http://dx.doi.org/10.3390/ijerph16152704 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kongtip, Pornpimol
Nankongnab, Noppanun
Kallayanatham, Nichcha
Pundee, Ritthirong
Choochouy, Nattagorn
Yimsabai, Jutharak
Woskie, Susan
Thyroid Hormones in Conventional and Organic Farmers in Thailand
title Thyroid Hormones in Conventional and Organic Farmers in Thailand
title_full Thyroid Hormones in Conventional and Organic Farmers in Thailand
title_fullStr Thyroid Hormones in Conventional and Organic Farmers in Thailand
title_full_unstemmed Thyroid Hormones in Conventional and Organic Farmers in Thailand
title_short Thyroid Hormones in Conventional and Organic Farmers in Thailand
title_sort thyroid hormones in conventional and organic farmers in thailand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695996/
https://www.ncbi.nlm.nih.gov/pubmed/31362416
http://dx.doi.org/10.3390/ijerph16152704
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