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Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model

If the alveolar bone height of patients requiring dental implants in the maxillary molar region is inadequate, it is difficult to achieve satisfactory outcomes using existing bone graft materials. We previously reported the possible utility of bacterial cellulose (BC) as a new dental treatment mater...

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Autores principales: Koike, Takashi, Sha, Jingjing, Bai, Yunpeng, Matsuda, Yuhei, Hideshima, Katsumi, Yamada, Takaya, Kanno, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696112/
https://www.ncbi.nlm.nih.gov/pubmed/31390730
http://dx.doi.org/10.3390/ma12152489
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author Koike, Takashi
Sha, Jingjing
Bai, Yunpeng
Matsuda, Yuhei
Hideshima, Katsumi
Yamada, Takaya
Kanno, Takahiro
author_facet Koike, Takashi
Sha, Jingjing
Bai, Yunpeng
Matsuda, Yuhei
Hideshima, Katsumi
Yamada, Takaya
Kanno, Takahiro
author_sort Koike, Takashi
collection PubMed
description If the alveolar bone height of patients requiring dental implants in the maxillary molar region is inadequate, it is difficult to achieve satisfactory outcomes using existing bone graft materials. We previously reported the possible utility of bacterial cellulose (BC) as a new dental treatment material. BC has a high absorptive capacity, good mechanical strength, and good volume retention. BC loaded with bone morphogenetic protein-2 (BMP-2) might allow effective alveolar bone augmentation. We created critical frontal bone defect models in 12 male Japanese white rabbits and divided them into four groups: sham; BC (BC grafting only); BMP-2 (treated with BMP-2 solution only); and BC+BMP-2 (grafted with BC loaded with BMP-2). Newly formed bone volume was calculated via hematoxylin-eosin staining evaluation. The proliferating cell nuclear antigen and osteocalcin levels were determined by the immunohistochemical staining analysis. All measured indices of the BC+BMP-2 group were significantly superior to those of the other groups (all p < 0.05). BC maintained the graft space and released BMP-2 in a sustained manner, promoting optimal bone formation. The BC+BMP-2 combination enhanced bone regeneration and shows promise as a useful means of clinical pre-dental implant bone augmentation in the maxillary sinus.
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spelling pubmed-66961122019-09-05 Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model Koike, Takashi Sha, Jingjing Bai, Yunpeng Matsuda, Yuhei Hideshima, Katsumi Yamada, Takaya Kanno, Takahiro Materials (Basel) Article If the alveolar bone height of patients requiring dental implants in the maxillary molar region is inadequate, it is difficult to achieve satisfactory outcomes using existing bone graft materials. We previously reported the possible utility of bacterial cellulose (BC) as a new dental treatment material. BC has a high absorptive capacity, good mechanical strength, and good volume retention. BC loaded with bone morphogenetic protein-2 (BMP-2) might allow effective alveolar bone augmentation. We created critical frontal bone defect models in 12 male Japanese white rabbits and divided them into four groups: sham; BC (BC grafting only); BMP-2 (treated with BMP-2 solution only); and BC+BMP-2 (grafted with BC loaded with BMP-2). Newly formed bone volume was calculated via hematoxylin-eosin staining evaluation. The proliferating cell nuclear antigen and osteocalcin levels were determined by the immunohistochemical staining analysis. All measured indices of the BC+BMP-2 group were significantly superior to those of the other groups (all p < 0.05). BC maintained the graft space and released BMP-2 in a sustained manner, promoting optimal bone formation. The BC+BMP-2 combination enhanced bone regeneration and shows promise as a useful means of clinical pre-dental implant bone augmentation in the maxillary sinus. MDPI 2019-08-06 /pmc/articles/PMC6696112/ /pubmed/31390730 http://dx.doi.org/10.3390/ma12152489 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koike, Takashi
Sha, Jingjing
Bai, Yunpeng
Matsuda, Yuhei
Hideshima, Katsumi
Yamada, Takaya
Kanno, Takahiro
Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title_full Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title_fullStr Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title_full_unstemmed Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title_short Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model
title_sort efficacy of bacterial cellulose as a carrier of bmp-2 for bone regeneration in a rabbit frontal sinus model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696112/
https://www.ncbi.nlm.nih.gov/pubmed/31390730
http://dx.doi.org/10.3390/ma12152489
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