Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highli...

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Detalles Bibliográficos
Autores principales: Ma, Dik-Lung, Wu, Chun, Wu, Ke-Jia, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696146/
https://www.ncbi.nlm.nih.gov/pubmed/31357712
http://dx.doi.org/10.3390/molecules24152739
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author Ma, Dik-Lung
Wu, Chun
Wu, Ke-Jia
Leung, Chung-Hang
author_facet Ma, Dik-Lung
Wu, Chun
Wu, Ke-Jia
Leung, Chung-Hang
author_sort Ma, Dik-Lung
collection PubMed
description Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.
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spelling pubmed-66961462019-09-05 Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells Ma, Dik-Lung Wu, Chun Wu, Ke-Jia Leung, Chung-Hang Molecules Review Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells. MDPI 2019-07-28 /pmc/articles/PMC6696146/ /pubmed/31357712 http://dx.doi.org/10.3390/molecules24152739 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Dik-Lung
Wu, Chun
Wu, Ke-Jia
Leung, Chung-Hang
Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title_full Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title_fullStr Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title_full_unstemmed Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title_short Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
title_sort iridium(iii) complexes targeting apoptotic cell death in cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696146/
https://www.ncbi.nlm.nih.gov/pubmed/31357712
http://dx.doi.org/10.3390/molecules24152739
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AT wuchun iridiumiiicomplexestargetingapoptoticcelldeathincancercells
AT wukejia iridiumiiicomplexestargetingapoptoticcelldeathincancercells
AT leungchunghang iridiumiiicomplexestargetingapoptoticcelldeathincancercells

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