Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046....

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Autores principales: Li, Jiao, Wang, Yujia, Hao, Xiaomeng, Li, Shasha, Jia, Jia, Guan, Yan, Peng, Zonggen, Bi, Hongkai, Xiao, Chunling, Cen, Shan, Gan, Maoluo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696147/
https://www.ncbi.nlm.nih.gov/pubmed/31382398
http://dx.doi.org/10.3390/molecules24152821
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author Li, Jiao
Wang, Yujia
Hao, Xiaomeng
Li, Shasha
Jia, Jia
Guan, Yan
Peng, Zonggen
Bi, Hongkai
Xiao, Chunling
Cen, Shan
Gan, Maoluo
author_facet Li, Jiao
Wang, Yujia
Hao, Xiaomeng
Li, Shasha
Jia, Jia
Guan, Yan
Peng, Zonggen
Bi, Hongkai
Xiao, Chunling
Cen, Shan
Gan, Maoluo
author_sort Li, Jiao
collection PubMed
description A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC(50) values ranging from 0.5 to 7.7 μM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL.
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spelling pubmed-66961472019-09-05 Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046 Li, Jiao Wang, Yujia Hao, Xiaomeng Li, Shasha Jia, Jia Guan, Yan Peng, Zonggen Bi, Hongkai Xiao, Chunling Cen, Shan Gan, Maoluo Molecules Article A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC(50) values ranging from 0.5 to 7.7 μM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL. MDPI 2019-08-02 /pmc/articles/PMC6696147/ /pubmed/31382398 http://dx.doi.org/10.3390/molecules24152821 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jiao
Wang, Yujia
Hao, Xiaomeng
Li, Shasha
Jia, Jia
Guan, Yan
Peng, Zonggen
Bi, Hongkai
Xiao, Chunling
Cen, Shan
Gan, Maoluo
Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title_full Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title_fullStr Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title_full_unstemmed Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title_short Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
title_sort broad-spectrum antiviral natural products from the marine-derived penicillium sp. imb17-046
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696147/
https://www.ncbi.nlm.nih.gov/pubmed/31382398
http://dx.doi.org/10.3390/molecules24152821
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