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Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age

At present, there is insufficient evidence on whether prenatal multi-micronutrient (MM) supplementation can be an antenatal nutritional intervention or not. This study aimed to explore the sustained effect of prenatal MM supplementation on early childhood health. A total of 939 mother–offspring pair...

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Autores principales: Cheng, Gang, Sha, Tingting, Gao, Xiao, Wu, Xialing, Tian, Qianling, Yang, Fan, Yan, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696317/
https://www.ncbi.nlm.nih.gov/pubmed/31374808
http://dx.doi.org/10.3390/ijerph16152744
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author Cheng, Gang
Sha, Tingting
Gao, Xiao
Wu, Xialing
Tian, Qianling
Yang, Fan
Yan, Yan
author_facet Cheng, Gang
Sha, Tingting
Gao, Xiao
Wu, Xialing
Tian, Qianling
Yang, Fan
Yan, Yan
author_sort Cheng, Gang
collection PubMed
description At present, there is insufficient evidence on whether prenatal multi-micronutrient (MM) supplementation can be an antenatal nutritional intervention or not. This study aimed to explore the sustained effect of prenatal MM supplementation on early childhood health. A total of 939 mother–offspring pairs were followed up in the study between 2015 to 2018 in Changsha, China. Information was mainly collected through household surveys at the ages of 1, 3, 6, 8, 12, 18, 24, and 36 months. General linear models and generalized estimating equation models were used to estimate the effects of maternal prenatal MM compared with IFA supplementation on infant growth and development. Offspring of women who used prenatal MM compared with IFA supplements had lower weight-for-age z score (WAZ) (adjusted β: −0.23, 95% CI: (−0.40, −0.06)) and weight-for-length z score (WLZ) (adjusted β: −0.20, 95% CI: (−0.37, −0.02)) at 3 months old, but a reduced risk of obesity at birth (aRR: 0.30, 95% CI: 0.11–0.78) and being overweight at 3 months old (aRR: 0.52, 95% CI: 0.32–0.84). Moreover, offspring of women who used prenatal MM compared with IFA supplements had significantly higher scores for communication (adjusted β: 0.41, 95% CI: 0.61–0.21), gross motor (adjusted β: 0.68, 95% CI: 0.49–0.88), fine motor (adjusted β: 1.64, 95% CI: 1.45–1.84), problem solving (adjusted β: 0.29, 95% CI: 0.10–0.49), and personal–social (adjusted β: 0.90, 95% CI: 0.70–1.10) skills at 36 months old. Prenatal MM supplementation could result in better infant growth in the first few months of life and improve development scores at the age of 3 years compared with IFA supplementation.
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spelling pubmed-66963172019-09-05 Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age Cheng, Gang Sha, Tingting Gao, Xiao Wu, Xialing Tian, Qianling Yang, Fan Yan, Yan Int J Environ Res Public Health Article At present, there is insufficient evidence on whether prenatal multi-micronutrient (MM) supplementation can be an antenatal nutritional intervention or not. This study aimed to explore the sustained effect of prenatal MM supplementation on early childhood health. A total of 939 mother–offspring pairs were followed up in the study between 2015 to 2018 in Changsha, China. Information was mainly collected through household surveys at the ages of 1, 3, 6, 8, 12, 18, 24, and 36 months. General linear models and generalized estimating equation models were used to estimate the effects of maternal prenatal MM compared with IFA supplementation on infant growth and development. Offspring of women who used prenatal MM compared with IFA supplements had lower weight-for-age z score (WAZ) (adjusted β: −0.23, 95% CI: (−0.40, −0.06)) and weight-for-length z score (WLZ) (adjusted β: −0.20, 95% CI: (−0.37, −0.02)) at 3 months old, but a reduced risk of obesity at birth (aRR: 0.30, 95% CI: 0.11–0.78) and being overweight at 3 months old (aRR: 0.52, 95% CI: 0.32–0.84). Moreover, offspring of women who used prenatal MM compared with IFA supplements had significantly higher scores for communication (adjusted β: 0.41, 95% CI: 0.61–0.21), gross motor (adjusted β: 0.68, 95% CI: 0.49–0.88), fine motor (adjusted β: 1.64, 95% CI: 1.45–1.84), problem solving (adjusted β: 0.29, 95% CI: 0.10–0.49), and personal–social (adjusted β: 0.90, 95% CI: 0.70–1.10) skills at 36 months old. Prenatal MM supplementation could result in better infant growth in the first few months of life and improve development scores at the age of 3 years compared with IFA supplementation. MDPI 2019-08-01 2019-08 /pmc/articles/PMC6696317/ /pubmed/31374808 http://dx.doi.org/10.3390/ijerph16152744 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Gang
Sha, Tingting
Gao, Xiao
Wu, Xialing
Tian, Qianling
Yang, Fan
Yan, Yan
Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title_full Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title_fullStr Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title_full_unstemmed Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title_short Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age
title_sort effects of maternal prenatal multi-micronutrient supplementation on growth and development until 3 years of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696317/
https://www.ncbi.nlm.nih.gov/pubmed/31374808
http://dx.doi.org/10.3390/ijerph16152744
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