Lignan Glycosides from Urena lobata

Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibit...

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Detalles Bibliográficos
Autores principales: Luo, Yuan, Su, Cong, Ding, Ning, Qi, Bowen, Jia, Fangfang, Xu, Xiping, Liu, Xiao, Wang, Juan, Wang, Xiaohui, Tu, Pengfei, Shi, Shepo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696325/
https://www.ncbi.nlm.nih.gov/pubmed/31390736
http://dx.doi.org/10.3390/molecules24152850
Descripción
Sumario:Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC(50) values in the range of 25.5–98.4 μM (positive control; quercetin; IC(50) = 7.2 ± 0.2 μM).

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